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20 Cards in this Set
- Front
- Back
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Transdermal Drug Delivery Systems (TDDS)
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systemic effects Utilize passive diffusion
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Transdermal Pathways:
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(1) sweat ducts - (2) continuous stratum corneum (3) hair follicles
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Across the continuous stratum corneum
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Transcellular route (thru)- •Intracellular route •Iontophoresis •Electroporation •Microneedle
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Factors Affecting Percutaneous Absorption
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Concentration • surface area • attract to skin better MW 100 – 800 Daltons • thin skin • duration
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Chemical Absorption Enhancers: hydration - open channels - ionization
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Ethanol, propylene glycol, PEG, sodium lauryl sulfate and DMSO (dimethylsulfoxide
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Iontophoresis (IP) - use current push ionic drug --- --- Iontocaine IONSYS
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Lidocaine, amino acids, peptides and steroids
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Iontophoresis (IP) Adv - Dis
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less AdEff - infect - More conpliance ====== irritation
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Iontocaine
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(brand of lidocaine 2% HCL with epinephrine topical solution 10 mins
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IONSYS
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on-demand fentanyl --- the upper outer arm or chest
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Sonophoresis (Phonophoresis) (about 20 kHz
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of a high molecular weight – analgesics and anti-inflammatory --- vibrate drug molecules and generally leads to enlargement of intracellular spaces - coupling agent ointment or cream
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TDDSs Adv
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no GIT -- ez ID - compliance - control plasma level (can stop any time) -
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TDDSs Dis adv
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only small MW --- expensive - inconvenience -- small amt
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1) An impermeable backing membrane
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Films of polypropylene, polyethylene, and polyolefin
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2. A drug reservoir or matrix system
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Stores and releases the drug at the skin site
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3. A rate-controlling membrane
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May or may not be present
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4. A release liner
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Removed before application and enables drug release
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5. An adhesive layer
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Maintains contact
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Matrix (Monolithic) TDDS
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The drug is uniformly distributed throughout a polymeric matrix
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Reservoir/Membrane TDDS
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- A rate-controlling membrane A small amount of drug is frequently placed in the adhesive layer to initiate prompt drug absorption
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Duragesic® - Fentanyl
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depot -- hot more drug in (faster )
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