Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
What are 3 nuclear transcription factors associated with Th1 cells?
|
T-bet
STAT-4 STAT-1 |
|
What is the "master regulator" of Th1 cell development?
|
T-bet
|
|
What are 4 nuclear transcription factors associated with Th2 cells?
|
GATA-3
MAF STAT-6 NFAT |
|
What is the "master regulator" of Th2 cell development?
|
GATA-3
|
|
What are 2 nuclear transcription factors associated with Th17 cells?
|
ROR-gamma-t
STAT-3 |
|
What is the "master regulator" of Th17 cells?
|
ROR-gamma-t
|
|
What is the "master regulator" of thymus-derived nTreg cells?
|
FOXP3
|
|
What are 3 primary functions of T-bet?
|
"Master regulator" of Th1 cells
Potentiates production of IFN-gamma Suppresses Th2 and Th17 development |
|
What is the primary function of STAT-4?
|
Production of IFN-gamma
|
|
What are the 2 primary functions of STAT-1?
|
Increases production of T-bet
Negative regulation of Th17 |
|
What are the 3 primary funcitons of GATA-3?
|
"Master regulator" of Th2 cells
Potentiates IL-4 expression Suppresses Th1 cytokines |
|
What are the 2 primary functions of MAF?
|
Contributes to IL-4 production
Inhibits IL-17 production |
|
What are the 2 primary functions of STAT-6?
|
Promotes Th2 differentiation
Negative regulator of T-bet and Th1 differentiation |
|
What is the primary function of NFAT?
|
Increases production of IL-4
|
|
What is the primary function of ROR-gamma-t?
|
"Master regulator" of Th17 differentiation.
|
|
What is the primary function of STAT-3?
|
Th17 differentiation
|
|
What is the primary function of FOXP3?
|
"Master regulator" of thymus-derived nTreg cells
|