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17 Cards in this Set

  • Front
  • Back
What are 3 nuclear transcription factors associated with Th1 cells?
T-bet
STAT-4
STAT-1
What is the "master regulator" of Th1 cell development?
T-bet
What are 4 nuclear transcription factors associated with Th2 cells?
GATA-3
MAF
STAT-6
NFAT
What is the "master regulator" of Th2 cell development?
GATA-3
What are 2 nuclear transcription factors associated with Th17 cells?
ROR-gamma-t
STAT-3
What is the "master regulator" of Th17 cells?
ROR-gamma-t
What is the "master regulator" of thymus-derived nTreg cells?
FOXP3
What are 3 primary functions of T-bet?
"Master regulator" of Th1 cells
Potentiates production of IFN-gamma
Suppresses Th2 and Th17 development
What is the primary function of STAT-4?
Production of IFN-gamma
What are the 2 primary functions of STAT-1?
Increases production of T-bet
Negative regulation of Th17
What are the 3 primary funcitons of GATA-3?
"Master regulator" of Th2 cells
Potentiates IL-4 expression
Suppresses Th1 cytokines
What are the 2 primary functions of MAF?
Contributes to IL-4 production
Inhibits IL-17 production
What are the 2 primary functions of STAT-6?
Promotes Th2 differentiation
Negative regulator of T-bet and Th1 differentiation
What is the primary function of NFAT?
Increases production of IL-4
What is the primary function of ROR-gamma-t?
"Master regulator" of Th17 differentiation.
What is the primary function of STAT-3?
Th17 differentiation
What is the primary function of FOXP3?
"Master regulator" of thymus-derived nTreg cells