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33 Cards in this Set

  • Front
  • Back
toxic principle of lupine and mode of action
quinolizidine alkaloids
-stimulation of nicotinic acetylcholine receptors
scientific name for lupine
lupinius
clinical signs of lupine ingestion
seizures
ataxia
head pressing
salivation
treatment and prognosis of lupine ingestion
no antidote
toxic principle of locoweed and mode of action
swainsonine
-inhibits alpha mannosidase (causes neuronal swelling and dysfxn)
scientific names for locoweed
oxytropis, astralagus
clinical signs of locoweed consumption
belligerent
depression
ataxia
excitable
loss of sense of direction
treatment and prognosis of locoweed toxicity
horses unsafe to ride, addiction occurs (peer pressure)
scientific name for larkspur
delphinium
toxic principle and mode of action of larkspur
polycyclic diterpene alkaloids
-neuromuscular blocking agents (competes with acetyl choline)
scientific names for locoweed
oxytropis, astralagus
clinical signs of locoweed consumption
belligerent
depression
ataxia
excitable
loss of sense of direction
treatment and prognosis of locoweed toxicity
horses unsafe to ride, addiction occurs (peer pressure)
scientific name for larkspur
delphinium
toxic principle and mode of action of larkspur
polycyclic diterpene alkaloids
-neuromuscular blocking (competes with acetyl choline-competitive inhibition)
clinical signs of larkspur toxicity
nervousness
paresis (weakness)
salivation
tremors
excitement
bloat
sudden death
treatment and prognosis of larkspur toxicity
detoxify-activated charcoal, cathartics
physostigmine
scientific name for braken fern
pteridium aquilinium
toxic principle and mode of action of braken fern toxicity
thiaminase -Vit B deficiency-cell shortage of ATP
ptaquiloside- bone marrow depression
clinical signs of braken fern toxicity
ataxia
weakness
blind staggers
weight loss
head pressing
death
treatment and prognosis of braken fern toxicity
long term exposure is guarded

thiamine administration
scientific name for poison hemlock
conium maculatum
toxic principle and mode of action of poison hemlock
coniine alkaloid
-stimulation and paralysis of nicotinic receptors (muscle stimulation and paralysis)
clinical signs of poison hemlock toxicity
nervous
convulsions
salivation
bloat
coma
sudden death
treatment and prognosis of poison hemlock toxicity
unlikely anything will change outcome
-evacuate stomach, respiratory support

-good prognosis with treatment
scientific name for water hemlock
cicuta
toxic principle and mode of action of water hemlock
cicutoxin
-seizure induction
clinical signs of water hemlock toxicity
violent seizures
salivation
muscle twitching
chomping of jaws
coma, death
treatment and prognosis of water hemlock toxicity
no antidote-will die
scientific name for groundsel and fiddleneck
groundsel-Senecio vulgaris)

fiddleneck-Amsinickia
toxic principle and mode of action of groundsel and fiddleneck
pyrrolizine alkaloids
-alkylate DNA
-liver cell necrosis and vascular lesions
clinical signs of groundsel and fiddleneck toxicity
depression
anorexia
head pressing, aimless walking
ataxia
drowsiness
treatment and prognosis of groundsel and fiddleneck toxicity
no antidote, supportive care