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7 Cards in this Set
- Front
- Back
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What are phenolic compounds used for?
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disinfecting, antiseptics, germicides and house cleaners
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What is the toxicity of phenolic compounds?
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LD 50 is .5g/kg for most mammales
cats are more sensitive due to their deficiency in conjugation to glucurnic acid |
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What is the mechanism of action of phenolic compounds?
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direct irritation causing coagulative necrosis
hepatictoxic, nephrotoxic and neurotoxic stimulates the respiratory center causing hyperventilation and maybe respiratory alkalosis resulting in systemic acidosis |
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What are the clinical signs of phenolic compounds?
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ataxia, weakness tremor, coma seizures, methemoglobinemia, respiratory alkalosis and icterus
dermal exposure causes coagulative necrosis, ulcers and white plaques associated with intense pain corneal damage characteristic phenolic odor on breath or on skin |
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What are the lesions associated with phenolic compounds?
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ulcerative and necrosis of the GI mucosa and the skin
liver and kidney changes |
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How do you laboratory diagnose phenolic compounds?
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detected in urine unchanged or as metabolites
proteinurea and hematuria elevated serum liver enzymes |
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How do you treat phenolic compound toxicosis?
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milk egg white or water followed by activated charcol and saline cartharitcs
do not induce vomiting supportive treatment |
