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8 Cards in this Set
- Front
- Back
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What is ivermectin?
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an endectocide for cattle, swine, and horses
prevention of heartworm disease in dogs and cats toxicity in collies and collie crosses and small birds |
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What is the mechanism of action of ivermectin?
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GABA agonist
GABA is a major inhibitory NT in the CNS of mammals |
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What are the clinical signs of ivermectin toxicosis?
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-mydriasis
-neurologic blindness -depression -stupor -ataxia -vomiting -drooling -tremor -coma -death |
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How do you laboratory diagnose ivermectin toxicosis?
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chemical analysis (generally not needed)
samples from the liver, body fat, GI contents and feces |
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How do you diagnose ivermectin toxicosis?
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history and clinical signs
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How do you treat ivermectin toxicosis?
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removal of ivermectin
-activated charcoal -saline cathartics Systomatic and supportive tratment -IV fluids -treat possible bradycardia Physostigmine IV in comatose patients |
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What is the specific antidote to ivermectin toxicity?
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Picrotoxin (GABA receptor antagonist)
has a narrow safety margin |
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What can you treat seizures due to picrotoxin with?
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barbiturates
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