Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
What are organochlorines?
|
-used as insecticides and ectoparasiticides
-very persistant in the environement -they are highly lipophilic soluble in oils and organic solvents -insoluble in water -general have low toxicity to mammals (cats are most sensitive) |
|
|
What is the MOA for organochlorines?
|
interferes with sodium channels in nerve membranes causing CNS stimulation and seizures
|
|
|
What are the clinical signs of organochlorine toxicosis?
|
-CNS stimulation
-salivation -nausea -vomiting -tremors -hyperthermia -abnormal posture -backwards walking (cattle) -depression (birds) |
|
|
What are the lesions associated with organochlorine toxicosis?
|
-minimal and nonspecific
-carcass may be bruised, lacerated and dirty from convulsions -see congestion and edema |
|
|
How so you diagnose organochlorine toxicosis with a lab?
|
chemical analysis - confirms acute tox
-brain concentrations are better correlated with toxicosis than fat concentrations -should be packaged separately |
|
|
How do you diagnose organochlorines?
|
history of exposure
clinical signs (seizure and neuromuscular signs), few lesions and chemical analysis |
|
|
What are the differential diagnoses for organochlorines in swine?
|
water deprivation/Na ion
pseudorabies |
|
|
What are the differential diagnoses for organochlines in dogs and cats?
|
strychnine
fluoroacetate lead organophosphates metaldehyde rabies |
|
|
What are the differential diagnoses for organochlorines in cattle?
|
-organophosphates
-lead -urea -polioencephalomalacia -infectious thromboembolic meningoencephlitis -ketosis -nervous forms of coccidiosis |
|
|
What is the treatment for organochlorines?
|
no specific treatment
-emetics -gastric lavage -bath animal for dermal exposure -diazepam or barbiturates to control CNS stimulation and seizures |
