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8 Cards in this Set
- Front
- Back
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What are Carbamate pesticides?
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insecticide that is mostly toxic to young animals or animals with deficient liver enzymes
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What is the MOA for Carbamates?
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-cause reversible inhibition of acetylcholinesterase
-Achetylcholinesterase can hydrolyze carbamate but at a slower rate than Ach |
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When do clinical signs of carbamate pesticide toxicosis occur?
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when the rate of carbaylation of achtylcholinesteraces exceeds the hydrolysis of carbamate by the enzyme
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What are the clinical signs of carbamate toxicosis?
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Same as organophosphates but less severe and shorter duration
-salivation, lacrimation, nasal discharge, increased respiratory sounds, diarrhea bradycardia -muscle fasciculations, tremors stiff gait -CNS depression |
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how do you diagnose carbamate pesticide toxicosis in the lab?
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refrigerated blood samples (do not dilute) analyze using rapid method
-pesticide undetectable in tissues blood or secretions because it is rapidly destroyed in the body |
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How do you diagnose carbamate pesticide toxicosis?
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-history
-clinical signs -lesions (or their absence) response to atropine therapy |
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How do you treat carbamate pesticide toxicosis?
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atropine sulfate 0.2 mg/kg
2 - PAM not effective |
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What is the prognosis of carbamate pesticide toxicosis?
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generally good if treatment is started soon after clinical signs
animals may survive without treatment if signs are not severe |
