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10 Cards in this Set
- Front
- Back
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What is amitraz?
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used in flea and tick collars and a plant insecticide
toxicosis by ingestion of the dip or collar or dermal absorption following dermal exposure |
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What is the acute toxicity for amitraz?
Subacute? |
acute oral LD50 is 100mg/kg
Subacute causes sedation in some dogs at 20mg/g stress increases toxicity |
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What is the mechanism of action for Amitraz?
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-alpha adrenergic agonist in the CNS
-alpha 1 and 2 adrenergic agonist in the ANS -weak MAO inhibitor |
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What are the clinical signs of Amitraz toxicosis?
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bradycardia
ataxia CNS depression hypothermia mydriasis anorexia vomiting diarrhea urination vocalization seizures (maybe) |
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What are lesions associated with amitraz toxicosis?
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non specific
hepatomegaly |
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What diagnostic laboratory findings can you see with amitraz?
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chemical analysis of the liver kidney, skin, brain lungs, adipose tissue or spleen
see hyperglycemia (due to inhibition of insulin) |
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How do you diagnose amitraz toxicosis?
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histoory
clinical signs lab diagnosis |
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What are differential diagnoses of amitraz toxicosis?
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Cholinesterase inhibitors
pyrethrins |
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How do you treat amitraz toxicosis?
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detoxification
-treat skin with soap and water -emetics or activated charcoal Supportive treatment -fluid therapy Antidotes -yohimbine or atipamezole |
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What is the prognosis of amitraz?
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good
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