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21 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What plants have colchicine?
MOA? |
Glory lily
antimiotic by binding to tubilin and inhibiting spindle formation during cell division rapid dividing cells are more sensitive |
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Name this plant
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Glory Lily
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Main toxic Principle: Colchicine alkaloid
Clinical Signs: Antimitotic and damage to all body organs including GI, cardiovascular, respiratory, CNS, hematopoietic |
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What plants are diterpene alkaloids?
MOA? |
larkspur, delphinium
monkshood,aconite competitive blockade of the nicotine receptors at the muscular endplate physostigmine or neostigmine is antidote |
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Name this plant
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larkspur,delphinium
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Main toxic Principle: Diterpene alklaoids
Clinical Signs: Sudden death and signs of neuromuscular blockade similar to curare, physostigmine or neostigmine is used as antidote |
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Name this plant
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monkshood aconite
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Main toxic Principle: Diterpene alkaloids
Clinical Signs: Sudden death, signs of neuromuscular blockade similar to curare, tachyarrhythmias, physostigmine or neostigmine is used as antidote |
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What plants have indolizine alkaloids?
MOA? |
locoweeds
inhibits lysosomal enzymes for glycoproteins neurotoxic see animals acting "crazy", depression, ataxic, circling, abnormal behavior |
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What plants have lycorine alkaloids?
MOA? |
narcissus
spider lily emetic and purgative bulb is most toxic see anorexia, salivation, diarrhea and hypotension |
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Name this plant
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Narcissus daffodil
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Main toxic Principle: Lycorine alkaloid in bulb, central ChE inhibitor, calcium oxlate crystals
Clinical Signs: Excessive salivation, severe vomiting and diarrhea, bradycardia, hypotension, convulsions, skin irritation |
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What plants have muscarine toxin?
MOA? |
poisonous mushroom
stimulation of muscarine cholinergic receptors CNS stimulation atropine is antidote |
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What plants have piperidine alkaloids?
MOA? |
poison hemlock
tobacco ave nicotinic effects starting with ganglionic and NM stimulation follow by blockade see ataxia, incoordination and birth defects |
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Name this plant
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Tobacco
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Main toxic Principle: Nicotine (pyridine alkaloid)
Clinical Signs: Vomiting, diarrhea, circulatory collapse, cardiac arrest, tremors, seizures, respiratory failure |
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What plants have Pyridine alkaloids?
MOA? |
tobacco
same as piperadine acts on nicotinic receptors at autonomic ganglia low doses cause depolarization large doses cause blockade see muscle twitching, muscle weakness and dyspnea |
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What plants are pyrroliziine alkaloids?
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rattlebox
senecio, groundsel and ragwort hepatotoxic |
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What plants are solanine and solanidine alkaloids?
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black nightshade
eggplant see GI, CNS, respiratory and cardiac signs |
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Name this plant
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Black nightshade
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Main toxic Principle: Solanine and solanidine alkaloids
Clinical Signs: Vomiting, mydriasis, drowsiness |
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Name this plant
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eggplant
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Main toxic Principle: Solanine and solanidine alkaloids
Clinical Signs: GI signs, signs similar to atropine |
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What plants are taxine alkaloids?
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japanese yew
cardio and GI toxic |
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What plants are tropane alkaloids?
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jimsonweed, thornapple, angel trumpet
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What plant has xanthine alkaloids?
MOA? |
cocoa
coffee blocks adenosine A receptors inhibits phosphodiesterase see CNS stimulation, tremors, tchycardia, hypotension, urination |
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Name this plant
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Cocoa
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Main toxic Principle: Theobromine (methylxanthine) alkaloid
Clinical Signs: Acts by competitive antagonism to adenosine receptors, signs include vomiting, diarrhea, urination, cardiac arrhythmias, muscle tremors, seizures, coma, death |
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Name this plant
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coffee
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Main toxic Principle: Methylxanthine alkaloids
Clinical Signs: GI signs, CNS stimulaion, muscle tremors, urination, tachycardia |
