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69 Cards in this Set
- Front
- Back
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Acetaminophen
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N-acetylcysteine
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Salicylate
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NaHCO3 (alkalinize urine)
Dialysis |
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Amphetamines
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NH4Cl (acidify urine)
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AChE inhbitors/organophosphates
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Atropine + pralidoxime
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Animuscarinic/Anticholinergic
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Physostigmine salicylate
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B-Blocker toxicity
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Glucagon
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Digitalis tox
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1. stop dig
2. normalize K+ 3. Anti-dig Fab fragment 4. Mg+2 |
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iron
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deferoxamine
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Lead
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CaEDTA, dimercaprol, succimer
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Copper, Arsenic, Gold
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Penicillamine
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Cyanide toxicity
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1. Nitrite -> meth binds CN
2. Thiosulfate: makes water soluble Hydroxocobalamin |
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Methemoglobin
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Methylene blue
Vitamin C |
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CO
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100% O2, hyperbaric O2
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Methanol
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Blindness
- Ethanol, dialysis - Fomepizole: inhibits Dehydrogenase |
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Ethylene glycol
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ATN
- EtOH, Dialysis - Fomepizole; inhibits dehydrogenase |
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opioids
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-opioid antagonist
Naloxone - longer acting Naltrexone |
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Benzo toxicity
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Flumazenil (benzo antagonist)
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TCA tox
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NaHCO3 (plasma alkalinization)
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Heparin tox
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Protamine
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Warfarin tox
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Vit. K
Fresh frozen plasma |
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tPA, streptokinase toxicity
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Aminocaproic acid
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Theophylline tox
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Beta blocker
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Cardiovascular Atropine-like effects
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TCAs
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Coronoary vasospasm
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Cocaine, sumatriptan
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Cutaneous flushing
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VANC
Vancomycin Adenosine Niacin Ca+ channel blocker |
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Dilated cardiomyopathy
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doxorubicin, danorubicin
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Torsades de pointes
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Class III (sotalol)
Class IA (quinidine) antiarrhythmics |
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Agranulocytosis
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clozapine - atypic antipsychotic
carbmazepine - anticonvulsant colchicine propylthiouracil, methimazole dapsone |
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Aplastic anemia
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dose independent - chloramphenicol
benzene, nsaids, PTU, methimazole |
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Direct Coombs positive HA
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methyldopa - central a2 agonists
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gray baby syndrome
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chloramphenicol
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hemolysis in G6PD pts
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IS PAIN
INH, Sulfonamide, Primaquine, aspirin, ibuprofen, nitrfurantoin |
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megaloblastic anemia
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Phenytoin (inhibit conjugase)
methotrexate, sulfa drugs |
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Thrombotic complications
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OCPs (estrogens and progestins)
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Cough
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ACEinhibitors
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Pulmonary Fibrosis
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Bleomycin, Amiodarone, busulfan
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Acute cholestatic hepatitis
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macrolides, erythromycin also prolongs QT
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Focal to massive hepatic necrosis
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halothane, valproate, acetaminophen, amanita phalloides
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hepatitis
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INH
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pseudomonas coloitis
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clindamycin, ampicillin
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gynecomastia
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Some Drugs Create Awesome Knockers
Spironolactone Digitalis Cimetidine chonic Alcohol Ketoconazole = also estrogens |
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Hot flash
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tomoxifen, clomiphene - SERMs partial agonists
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Hypothyroidism
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lithium, amiodarone
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Lithium Side Effects
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LMNOP
Lithium Movement (tremor) Nephrogenic DI hypOthyroid Prego problems - ebstein's |
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gingival hyperplasia
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phenytoin
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gout
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furosemide, thiazide
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Osteoporosis
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corticosteroids, heparin
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photosensitive
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Sulfonamides, Amiodarone, Tetracycline
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Rash (SJS)
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ethosuximide, lamotrigine, carbamazepine, phenobarbitol, phenytoin, sulfa drugs, penicillin, allopurinol
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SLE-like
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Hydralazine
Procainamide Phenytoin INH |
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Tendonitis/tendon rupture
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fluoroquinolones
- floxacin |
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Fanconi's syndrome
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expired tetracycline
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interstitial nephritis
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methicillin, NSAIDs, furosemide
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Hemorrhagic cystitis
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cyclophosphamide
ifosfamide (prevent w/ mesna) |
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Cinchonism
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flushed, sweating, deaf
- Quinidine, quinine |
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Diabetes insipidus
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Lithium , demeclocyline (tetracycline)
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Parkinson-like symptoms
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Haloperidol, trifuloperazine, fluphenazine
- chlorpromazine - reserpine - metoclopramide (D2 antagonist used to increase diabetic and post-surgery gastroparesis) |
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Seizures
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Bupropion - smoking cessation, inc NE, seizure in bulimics
imipenem/cilastatin (Beta-lactamase resistant carabapenem used for anerobes, cilastatin inhibits dihydropeptiridase I to inc. conc of imipenem) INH |
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Tardive dyskinesia
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antipsychotic
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Disulfiram like rxn
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metronidazole
- some cephalosporins procarbazine (chemo) 1st gen sulfonylureas: tolbutamide, chlorpropamide |
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Nephrotoxic/neurotoxic
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polymyxin (resistant gram neg infxns, basic cationic binds membranes acts like detergent)
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nephrotoxic/ototoxic
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aminoglycosides, vancomycin, loop diuretics, cisplatin
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P-450 inducer
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quinidine (can also inhibit but this not as important)
Barbituates St. john's wort Phenytoin; phenobarbitol Rifampin Griseofulvin Carbamazepine Chronic Alchol |
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P-450 inhibitor
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SIC KEG acute
sulfonamide INH Cimetidien ketoconazole erythromycin (macrolide- except azithromycin) Grapefruit juice (inhibit statin) Acute EtOH, Amiodarone |
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ethylene glycol, methanol metabolites
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oxalic acid = ATN
formic acid = retinal damage |
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Fomepizole
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alchol dehydrogenase inhbitor
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Disulfiram
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Acetaldehyde dehydrogenase inhibitor
- acetaldehyde builup causes hangover |
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EtOH met
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- inc NADH from pyruvate -> lactate
- makes DHAP -> glycerol 3-phosphate; Acetic acid -> FAs and ketones |
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Sulfa drugs
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Celecoxib - cox-2
probenecid - gout sulfasalazine furosemide, thiazides, acetazolamide TMP-SMX sulfonylurea antibiotics |
