Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
Definition: Following chemical exposure potentially leading to abnormal development. Study of Pharmacokinetics, Mechanisms, Pathogenesis, and outcomes
|
Developmental Toxicology
|
|
|
What outcomes are included in Developmental tox?
|
-Structural malformations
- Growth retardation - Functional impairment and/or -death |
|
|
When was the 1st induced birth defects in mammalian species?
|
1930's
|
|
|
What did the 1st induced birth defects in mammalian species consist of?
|
Experimental maternal nutrient deficiences.. Anophthalmia and cleft palate
|
|
|
What year did maternal dietary deficiencies and other environmental factors--> affects intrauterine development?
|
1940's
|
|
|
What year? Chemical, physical agent exposure in mammals--> malformations.
-nitrogen mustard, trypan blue, hormones, antimetabolites, alkylating agents, hypoxia, x-rays, and others |
1940's-->1960's
|
|
|
If an eye (ophthalmia) does not grow to full size and is smaller, than it should be this is known as .... If the eye does not grow at all it is ......
|
Microphthalmia.
Anophthalmia. |
|
|
* Decreased uterine blood flow
*Maternal anemia * Altered nutritional status * Toxemia *Altered Organ function *Autoimmune states * Diabetes *Electrolyte or acid base disturbances *decreased milk quantity/quality *abnormal behavior --- These outline the relationship between... |
maternal and developmental toxicology
|
|
|
Definition: number of births for a woman
|
Parity
|
|
|
Definition: Predisposition to respond to a toxic insult
|
Maternal susceptibility
|
