Toxicities And Antidoes

Front 1

Acetaminophen

Back 1

N-acetylcyteine (increases glutathione stores to reduce hepatotoxicity)

Front 2

Salicylates

Back 2

NaHCO3 (alkanize urine), dialysis

Front 3

Amphetimines

Back 3

NH4Cl (acidify Urine)

Front 4

Anticholinestersases, organophoshates

Back 4

Atropine, pralidoxime

Front 5

Antimuscaranic, Anticholinergic

Back 5

Physostigmine Salicylate

Front 6

B-blockers

Back 6

Glucagon

Front 7

Digitalis

Back 7

Stop dig, Normalize K, lidocaine, anti-dig FAB fragments and Mg

Front 8

Iron

Back 8

Deferoxamine (chelator)

Front 9

Lead, Mercury

Back 9

CaEDTA, Dimercaprol, Succimer for kids, penicillinamine (chelators)

EDTA = ethylene Diamine TetraAcetic Acid

Front 10

Arsenic, gold

Back 10

Dimercaprol (chelating Agent)

Front 11

Copper, arsenic

Back 11

Penicillamine - copper chelator

Front 12

Cyanide

Back 12

Nitrite, hydrocobalamin, thiosulfate.
Nitrites make Methemoglobin, which binds cyanide
Thiosulfate binds with cyanide so it becomes renally excreted

Front 13

Methemoglobin

Back 13

Methylene Blue- reduced Methehmoglobin back to hemoglobin

Front 14

Carbon Monoxide

Back 14

100% 02

Front 15

Methanol, Ethylene Glycol

Back 15

Ethanol, dialysis, fomepizole

Fomepizole - inhibits Alcohol Dehydrogenase, which is the first step in metabolism of methanol and ethylene glycol

Front 16

Opiods

Back 16

Naloxone, Naltrexone

Front 17

Benzodiazepines

Back 17

Flumazenil - benzodiazepine competitive inhibitor

Front 18

TCA's

Back 18

NaHCO3 (serum alkanization)

Front 19

Heparin

Back 19

Protamine Sulfate - binds to heparin

Front 20

Warfarin

Back 20

Vitamin K, Fresh Frozen Plasma (immediately)

Front 21

tPA (alteprase), Streptokinase

Back 21

Aminocaproid Acid - lysine analogue, binds to plasminogen so it cannot be activated to plasmin and degrade fibrin

Front 22

Atropine Like side effects (dry as a bone, mad as a hatter...)(1)

Back 22

Tricyclic antidepressants (amitryptalines, -ipramines)- for arythmias give sodium bicarbonate

Front 23

Coronary Vasospasm (2)

Back 23

Cocaine, sumatriptan (used for migraines)

Front 24

Cutaneous flushing (4)

Back 24

Niacin (block with aspirin), Calcium channel blockers (nifedipine) adenosine (lasts a few seconds), vancomycin

Front 25

Dilated Cardiomyopathy (2)

Back 25

DNA intercalatars - Doxorubicin (adriamycin), duanorubicin

Front 26

Torsades De Pointe (3)

Back 26

Class III AA's (sotalol, NOT amiodarone), class IA (quinidine), cisapride

Front 27

Agranulocytosis (5)

Back 27

Carbamazepine, Clozapine, colchicine, propylthiouracil, methimazole

Front 28

Aplastic Anemia (5)

Back 28

Chloramphenicol, benzene, NSAIDS, Propylthiouracil, methimazole

Front 29

Direct coombs test positive hemolytic anemia (1)

Back 29

Alpha Methyl-dopa - central alpha 2 agonist

Front 30

Gray baby syndrome (1)

Back 30

Chloramphenicol

Front 31

Hemolysis in G6PD (7)

Back 31

Isoniazid, Sulfonamides, Primaquine, Aspirin,, ibuprofren, nitrofurantoid, DAPSONE (not in first aid)
(IS PAIN D)

Front 32

Thrombotic Comlplications (1)

Back 32

OCP's (progestin and estrogens)

Front 33

Cough (1)

Back 33

Ace inhitors -captopril. Use losartan instead

Front 34

Pulmonary Fibrosis (3)

Back 34

Bleomycin, busulfan, amiodarone

Front 35

Acute Cholestatic Hepatitis (1)

Back 35

Erythromycin (Macrolides) - inhibit 23s of 50s, no translocation

Front 36

Focal to massive hepatic necrosis (5)

Back 36

Halothane, valproic acid, acetaminophen, amanita phalloides (mushroom), carbamazepines (not in first aid)

Front 37

Hepatitis (class of drugs)

Back 37

All of the anti-TB drugs, especially isoniazid

Front 38

Pseudomembranous Colitis (2)

Back 38

Clindamycin and Ampicillin

Front 39

Adrenocortical insufficiency (1)

Back 39

Glucocorticoid withdrawal (glucocorticoids cause blocking of HPA axis)

Front 40

Gynecomastia (6)

Back 40

Some (spironolactone)Drugs (digitilas) create (cemitidine) awesome (chronic alcohlism) Knockers (ketoconazole) easily (estrogen)

Front 41

Hot flashes (2)

Back 41

Tamoxifen, clomiphene

Front 42

Gingivial Hyperplasia (1)

Back 42

Phenytoin

Front 43

Gout (2 diuretics and a cards drug)

Back 43

Furosemide, thiazides, Niacin (according to world)

Front 44

Osteoporosis (2)

Back 44

Corticosteroids, heparin

Front 45

Photosensitivity (3)

Back 45

SAT for photo- S= Sulfonamides, A=amiodarone, T = tetracyclines

Front 46

SLE-like syndrome (4)

Back 46

Hydralizine, Isoniozid, Procainamide, Phenytoin

Front 47

Tendonitits, tendon rupture, damage, cartiliadge damage (1)

Back 47

Fluroquinalones

Front 48

Fanconi's Syndrome (1)

Back 48

Expired Tetracycline

Front 49

Interstitial Nephritis (eosinophils in urine)(3)

Back 49

NSAIDS, Nafcillin/methcillin, Sulfonamides

Front 50

Hemorrhagic Cystitis

Back 50

Cyclophosphamide, ifosfamide

Front 51

Cinchonism (hearling loss, somnolcence, ringing in ear)

Back 51

Quinidine, quinine

Front 52

Diabetes Insipidus (2)

Back 52

Lithium, Demeclocycline (treatment for SIADH, is a tetracyclin type)- Treat with hydrochlorothiazide

Front 53

Seizures (2)

Back 53

Buproprion, imipenem/cilastatin

Front 54

Tardive Dyskinesia (facial stuff)(1 class)

Back 54

Antipsychotics (haloperidol +azines)

Front 55

Disulfiram-like reaction (4)

Back 55

Metronidazole, certain cephalosporins, procarbazine, 1st generation sulfonylureas

Front 56

Nephrotoxicity/Neurotoxicity

Back 56

Polymyxins

Front 57

Nephrotoxicity/Ototoxicity

Back 57

Aminoglycosides (neprhotoxicity increased by ceopahlosporins), loop diuretics, cisplatin