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14 Cards in this Set
- Front
- Back
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What is the result of drugs exerting a toic effect on the sarcolemma? What may precipitate rhabdomyolysis?
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Necrosis. Electrolyte imbalances.
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What drugs may cuase an insidiuos or rapidly developly necrotizing myopathy?
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Cholesterol reducers: clofibrate, gemfibrozole, 3-HMG-CoA reductase inhibitors (statins), and niacin.
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What feature of amphiphilic drugs cause autophagic lysosomal myopathy? What does it facilitiate?
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The hydrophobic group & hydrophilic pos. charged amine group. Interaction with the anionic phospholipids of cell membrances and organelles.
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What 2 drugs may cause both neuropathies and myopathies?
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Chloroquine and amiodorone (antiarrhythmic)
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What are the fx's of colchicine?
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It is a weakly amphiphilic drug that prevents tubulin polymerization. It causes both neuromyopathy, and may induce renal failure.
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What drugs induces mitochondrial myopathy? What do pt's present with? What is tricky about its sequalae?
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Zidovudine (AZT). Weakness and myalgia. It may be difficult to distinguish from myopathy assoc'd with HIV infection.
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What are 3 other drugs that may induce inflammatory myopathies?
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Trytophan, D-penicillamine, & procainamide
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What drug at 30mg/d is associated with an inc. risk of myopathy 2nd to impaired protein synthesis or catabolism?
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Prednisone.
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Pt's with adverse rxn to prednisone therapy present with these symptoms
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Proximal muscle weakness and atrophy assoc'd with Cushingoid appearance (moon facies, truncal obesity, hyperpigmentation)
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What may result from the use of high dose IV corticosteroids?
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Acute onset of severe generalized weakness.
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What may result from the use of high dose IV corticosteroids?
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Acute onset of severe generalized weakness.
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What is a syndrome that may occur due to prednisone use in the ICU?
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Acute quadriplegic myopathy
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What agents used along with high does IV cortisteroids may cause an acute onset of generalized weakness?
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NM blocking agents.
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This drug, otherwise known as IPECAC, at high overuse may cause profound proximal myopathy and cardiomyopathy?
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Emetine
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