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93 Cards in this Set
- Front
- Back
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Induction dose of Propofol
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1-2.5 mg/kg
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Maintenence dose of Propofol
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100-200 mcg/kg/min
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Onset/Peak/Duration of Propofol
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30 secs/1min/5-10min
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Mechanism of action of Propofol
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GABA mimetic effects.
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Concious sedation dose of Propofol
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25-75 mcg/kg/min
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Side effects of Propofol administration
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Hypotension
Apnea histamine release supress adrenal cortex and plasma cortisol levels |
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Induction dose of Etomidate
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0.1-0.4 mg/kg
5-20 mcg/kg/min |
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O/P/D of etomidate
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30-60 secs/1min/3-10 mins
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Mechanism of action of Etomidate
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GABA mimetic
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Metabolism of propofol occurs where?
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Liver
Lungs Urine |
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Metabolism of Etomidate occurs where?
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Hydrolysis by plasma and hepatic enzymes
Urine |
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Side effects of Etomidate administration
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Hypotension
MYOCLONUS Adrenocort suppresion x48 hrs Inhibits 11 Beta hydroxylase |
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Induction dose of Succinylcholine
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0.7-1 mg/kg
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O/P/D of Succinylcholine
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30-60 secs/60 secs/ 4-6 mins
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Mechanism of action of Succinylcholine
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Depolerizes cholinergic receptors at motor end plate
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Odansetron (Zofran) dosage
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4-16 mg
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O/P/D of Zofran
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30 min/variable/12-24 hr
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Mechanism of action of Zofran
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Selective seratonin 5-ht3 receptor antagonist in CTZ
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Side effects of Zofran administration
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extrapyramidal symptoms
hepatic dysfunction Hypokalemia QT prolongation |
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Esmolol dosage
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25-100mg q 5 min
50-300mcg/kg/min |
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O/P/D of Esmolol
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1-2 min/ 5min / 10-20 min
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Mechanism of action of Esmolol
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Selective Beta 1 Blocker
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Side effects of Esmolol administration
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Bradycardia
Hypotension Bronchospasm |
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Induction dose of Vecuronium
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0.08 - 0.1 mg/kg
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Drip dose of Vecuronium
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1-2 mics/kg/min
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O/P/D of Vecuronium
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1-3min/3-5 min/ 25-30 min
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Mechanism of Action of Vecuronium
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NMB competes for cholinergic receptors at motor end plate
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Side effects of vecuronium
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brady, prolonged block
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Induction dose of succinylcholine
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0.7 - 1 mg/kg
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O/P/D of Succinylcholine
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30-60 secs/ 60 secs/ 4-6 mins
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Mechanism of action of succinylcholine
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Depolarizes cholinergic receptors at motor end plate.
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Side effects of Succinylcholine administration
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MH,
hyperkalemia, Inc IOP, inc lower esophageal sphincter tone |
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Dosage of Naloxone
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0.1-2.0 mg repeat Q 2-3 min
Max: 10 mg |
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O/P/D of nalaxone
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1-2 min/ 5-15 min/ 1-4 hr
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Mechanism of action of Naloxone
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Competitively inhibits opiates at mu, kappa, and delta receptors
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Side effects of nalaxone administration
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Inc SNS activity - tachy, htn , NV
Reversal of analgesia pulmonary edema |
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Dose of neostigmine
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0.05 mg/kg
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O/P/D of neostigmine
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2-3 min/ 3-14min / 40-60 min
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Mechanism of action of neostigmine
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inhibits hydrolysis of Ach(via AchEsterase inhibition)
Antagonizes ND-NMR |
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Side effects of neostigmine administration
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Brady
Secretions NV C/l with peritonitis GI obstruction CAUTION: w/ asthma, brady recent MI, seizure disorder, hyperthyroidism |
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Dose of Glycopyrrolate
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0.01 mg/kg
0.4 - 0.8 mg inh for bronchospasm |
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O/P/D of glycopyrrolate
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30-60 secs/5 min/2-3 hr
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Mechanism of action of glycopyrrolate
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Inhibits action of Ach by binding to muscarinic cholinergic receptors
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Side effects of glycopyrrolate
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Tachy (high doses)
Brady ( low doses) confusion urinary retention |
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Dose of Metoclopromide
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10 mg
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O/P/D of metoclopramide
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1-3 min/ <1hr/ 1-2 hr
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Mechanism of action of metoclopramide
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Sensitizes GI smooth muscle to Ach
Antagonizes central and peripheral DA rec, stimulates upper GI motility C/I with epilepsy |
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Side effects of metoclopramide
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Drowsiness
Extrapyramidal symptoms diarrhea hypoglycemia |
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Dose of ondansetron
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4-16mg
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O/P/D of Ondansetron
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30 min/ variable / 12-24 hr
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Dose of Labetolol
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2.5-20 mg
0.5- 2 mg/min |
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O/P/D of labatolol
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2-5 min/5-15 min/ 2-4 hr
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Mechanism of action of Labetolol
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Adrenergic receptor blocker with mild a1 and predominant B (B1 and B2)
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side effects of Labetolol
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Bradycardia
hypotension dyspnea bronchospasm CHF Inc resistance to B agonist bronchodilators |
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Metoprolol dosage
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5-15 mg
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O/P/D of metoprolol
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10-20 secs/20 min/ 5-8 hr
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side effects of Labetolol
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Bradycardia
hypotension dyspnea bronchospasm CHF Inc resistance to B agonist bronchodilators |
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Mechanism of action of metoprolol
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Primary B1 blocker with some B2 activity
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Metoprolol dosage
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5-15 mg
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side effects of metoprolol
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hypotension
dyspnea bronchospasm |
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O/P/D of metoprolol
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10-20 secs/20 min/ 5-8 hr
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Furosemide dose
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5-40mg over 1-2 mins
(Drip: NTE 4 mg/min) |
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Mechanism of action of metoprolol
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Primary B1 blocker with some B2 activity
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O/P/D of Furosemide
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5-15 min/ 20-60 min/ 2 hr
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side effects of metoprolol
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hypotension
dyspnea bronchospasm |
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Mechanism of action of Furosemide
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Inhibits reabsorption of Na and Cl at the loop of Henle, causes vasodilation
Dec CSF production |
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Furosemide dose
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5-40mg over 1-2 mins
(Drip: NTE 4 mg/min) |
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Side effects of Furosemide
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Orthostatic hypotension
Hyperglycemia Hypokalemia |
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O/P/D of Furosemide
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5-15 min/ 20-60 min/ 2 hr
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Hydrocortisone Dose
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Anti- inflammatory: 20-300 mg Q 2-10 hr
Steroid Replacement: 50-100 mg pre- , intra-, post op |
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Mechanism of action of Furosemide
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Inhibits reabsorption of Na and Cl at the loop of Henle, causes vasodilation
Dec CSF production |
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Side effects of Furosemide
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Orthostatic hypotension
Hyperglycemia Hypokalemia |
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Hydrocortisone Dose
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Anti- inflammatory: 20-300 mg Q 2-10 hr
Steroid Replacement: 50-100 mg pre- , intra-, post op |
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O/P/D of hydrocortisone
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3-5 min/ <1hr/ 30- 36 hr
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mechanism of action of hydrocortisone
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Inc. amount of steroid in circulation. a corticosteroid.
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Side effects of hydrocortisone
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Na retention, hypokalemia, hyperglycemia, inc infection rate
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Dose of dexamethasone
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8-25 mg
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O/P/D of dexamethasone
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3-5min/ 12-24 hr/ 36-54 hr
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Mechanism of action of dexamethasone
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Decreases action of inflammatory cells, gluco and mineralocorticoid effects
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Side effects of dexamethasone
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fluid retention
hyperglycemia inc IOP dec wound healing HTN |
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Dose of Cefoxitin
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1-2 g, 30 min prior
Q 6 hr |
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duration of Cefoxitin
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6-8 hr
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Mechanism of action of cefoxitin
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inhibits cell wall synthesis of gram negative/positive organisms
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side effects of cefoxitin
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local reactions
diarrhea NV |
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Dose of cefuroxime
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0.75- 1.5 g 30 min prior
Q 12 hr |
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Duration of cefuroxime
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8 hr
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Mechanism of action of cefuroxime
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inhibits mucopeptide synthesis in cell wall
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Side effects of cefuroxime
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local reactions
diarrhea renal/hepatic dysfunction |
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Dose of ketorolac
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30 mg IV (60 mg IM)
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O/P/D of Ketorolac
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30-60 secs/ 1-3 hr / 3-7 hr
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Mechanism of action of Ketorolac
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NSAID - inhibits synthesis of prostaglandins
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Side effects of ketorolac
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bleeding, gastric ulcers, renal/hepatic dysfunction
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Side effects of CaCl administration
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HTN
Arrhythmias Lethargy Hypercalcemia Goal: 8.5-10 mg/dl (arrhythmias with digoxin) |
