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19 Cards in this Set
- Front
- Back
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Avastin (Bevacuzimab)
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Various Cancers
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Epogen, procrit
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Anemia
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Enbrel
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Rheumatoid arthritis (RA) or Ankylosing spondylitis (AS)
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Herceptin (trastuzumab)
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Breast Cancer
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Humira (Adalimumab)
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rheumatoid arthritis (RA) and psoriatic arthritis (PA)
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Lantus
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Diabetes
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Neulasta
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Neutropenia
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Novolog
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Diabetes
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Remicade (Infliximab)
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Inflammatory disorders
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Rituximab, Rituxan
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RA and Non-Hodkin's Lymphoma
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Aranesp (Darbepoetin)
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anemia
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Gardasil
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HPV prevention
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What are the aspects to consider in formulating a biotech product?
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- Choice of the delivery system
-Route of administration - Target specific devliery - Stability - Bioavalability |
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Why is a solubility enhancers needed for biotech drugs? Give 3 examples.
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Because proteins have a tendency to aggregate and precipitate.
Ex. Surfactant Na Dodecyl sulfate amino acids- arginine and lysine |
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Why is an anti-adsorption and anti-aggregation agent needed for? Give three examples.
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To prevent adsorption of proteins to surfaces (especially hydrophobis and to prevent aggregation of proteins .
Albumin competes with the site of absorption Surfactants |
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Why is a buffer needed? Three examples?
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pH affects physical and chemical stability.
Sodium phosphate buffer, acetate buffer and citrate buffer. |
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Give two example of anti-oxidants and three examples of preservatives.
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Ascorbic acid and acetyl-cysteine.
benzyl alcohol, phenol, and chlorobutanol |
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Why are osmotic agents used? Give four examples.
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To adjust the tonicity or parental protein products.
saline sugars poly hydrates alcohol |
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Name 5 types of excipients used in biotech manufact
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Solubility enhancers
anti-adsorption and anti-aggregation agents Buffers preservatives/ antioxidants osmotic agents |
