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2 Cards in this Set
- Front
- Back
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Hydrocodone w/ APAP/Vicodin
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- Narcotic Analgesic & antitussive
- Opiod derived from codeine & thebaine - Psychological & physical addiction - Dispensed 5-10mg w/ 500 mg of acetaminophen - DEA schedule III (5-10 mg) - DEA schedule II ( >15 mg) - SE: Respiratory depression; N/V; constipation - MOA: Binds to mu receptors in brain and spinal cord reducing pt perception of pn. Acetaminophen selectively blocks a variant of COX separate than 1 or 2 |
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Acetaminophen
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- Found in cerebral cortex & heart = COX 3
- COX 3: reduces pn and fever w/o reduction in inflamm - Metabolized by PHASE II metabolism; utilizes sulfate & glucuronide - Cyt P450 2E1 & P450 3A4 convert to NAPQI (n acetyl p benzo quinone imine) which has high rate of hepatic toxicity; rqrs glutathione - Decreased lvls of glutithione may precipitate acute hepatic necrosis |
