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10 Cards in this Set
- Front
- Back
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LTQ1
Gene: Effect: Typical resting ECG QT change w/ exercise QT change Mexiletine Beta Blocker response |
gene: KCNQ1
Effect: decreased I (ks) an adrenergic sensitive potassium current channel. Slow delayed rectifier. Typical resting ECG: Broad T wave QT change w/ exercise: Failure to shorten QT shortening w/ Mexiletine: NO Clinical response Beta blockers: YES |
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LTQ2
Gene: Effect: Typical resting ECG QT change w/ exercise QT change Mexiletine Beta Blocker response |
gene: KCNH2
Effect: decreased I (kr) an rapid delayed rectifier. Typical resting ECG: low amplitude T wave w/ notching QT change w/ exercise: NORMAL QT shortening w/ Mexiletine: NO Clinical response Beta blockers: YES, less than LTQ1 |
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LTQ3
Gene: Effect: Typical resting ECG QT change w/ exercise QT change Mexiletine Beta Blocker response |
gene: SCN5A
Effect: Increased plateau I (Na) Typical resting ECG: Long isoeletric ST segment QT change w/ exercise: SUPRANORMAL QT shortening w/ Mexiletine: YES Clinical response Beta blockers: UNCERTAIN |
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Treatment prolonged QTc interval
(define prolonged) |
(>460ms-F & >440ms-M)
beta blockers |
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Treatment Survivors of Cardiac arrest
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Implantable cardioverter-defibrillator
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Treatment Patients syncope while on beta blocker
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Implantable cardioverter-defibrillator
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High risk genetic + clinical
(define) treatment opinion |
Genetic-LQT2 & LQT3
Clinical - QTc > 500ms Opinion-ably Implantable cardioverter-defibrillator |
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Type beta blocker used (Name)
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long acting agents (atenolol or nadolol)
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Causes Acquired prolonged QT
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Anti arrhythmic agents (sotalol & dofetilide)
Haloperidol Methadone Pentamidine |
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States causing prolonged QT
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hypocalcemia
hypothyroidism |
