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26 Cards in this Set
- Front
- Back
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Schizophrenia
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idiopathic psychosis (>6 months) with disordered thinking and emotional withdrawal
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disorganized symptoms
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odd behavior and speech
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positive symptoms
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delusions and auditory hallucinations
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negative symptoms
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apathy, anergia, asocial
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DA hypothesis
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hypoactivity of mesocortical pw --> negative symptoms and disinhibits mesolimbic pw --> positive symptoms and hyperactivity
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5HT2 Hypothesis
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increased 5HT2A mediated activity --> mesocortical DA --> negative symptoms
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D2 block
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chlorpromazine, thioridazine, fluphenazine, haloperidol
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5HT2A > D2 block
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clozapine
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Neuroleptic SEs
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EPS
hyperprolactineimia anti-muscarinic effects hypotension sexual dysfunction sedation weight gain |
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EPS
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acute dystonia
akathisia parkinsonism peri-oral tremor neuroleptic malignant syndrome |
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anti-muscarinic drugs may worsen
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hyperthermia of neuroleptic malignant syndrome (rigidity and stupor as well) and tardive dyskinesia
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Tardive Dyskinesia
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repetitive involuntary movements that occur upon withdrawal from chronic antipyschotics
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treat TD with
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clozapine
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DA and Prolactin
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dopamine inhibits prolactin release
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antipsychotic potency and EPS
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direct correlation
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antimuscarinic activity and EPS
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inverse correlation
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act on positive and negative symptoms
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clozapine
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decreased risk of EPS and TD
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clozapine
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little or no prolactin release
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clozapine
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cutaneous reactions
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chlorpromazine
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retinal deposits, leukocytosis and leukopenia, and ventricular arrhythmias
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thioridazine
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agranulocytosis
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clozapine
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neuroleptics and seizures
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neuroleptics decrease seizure threshold
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depot preparation for non-compliant patients
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fluphenazine and risperidone
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used to treat Tourette's and Huntington's
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Haloperidol
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act at chemreceptor trigger zone
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chlorpromazine and haloperidol
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