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26 Cards in this Set

  • Front
  • Back
Schizophrenia
idiopathic psychosis (>6 months) with disordered thinking and emotional withdrawal
disorganized symptoms
odd behavior and speech
positive symptoms
delusions and auditory hallucinations
negative symptoms
apathy, anergia, asocial
DA hypothesis
hypoactivity of mesocortical pw --> negative symptoms and disinhibits mesolimbic pw --> positive symptoms and hyperactivity
5HT2 Hypothesis
increased 5HT2A mediated activity --> mesocortical DA --> negative symptoms
D2 block
chlorpromazine, thioridazine, fluphenazine, haloperidol
5HT2A > D2 block
clozapine
Neuroleptic SEs
EPS
hyperprolactineimia
anti-muscarinic effects
hypotension
sexual dysfunction
sedation
weight gain
EPS
acute dystonia
akathisia
parkinsonism
peri-oral tremor
neuroleptic malignant syndrome
anti-muscarinic drugs may worsen
hyperthermia of neuroleptic malignant syndrome (rigidity and stupor as well) and tardive dyskinesia
Tardive Dyskinesia
repetitive involuntary movements that occur upon withdrawal from chronic antipyschotics
treat TD with
clozapine
DA and Prolactin
dopamine inhibits prolactin release
antipsychotic potency and EPS
direct correlation
antimuscarinic activity and EPS
inverse correlation
act on positive and negative symptoms
clozapine
decreased risk of EPS and TD
clozapine
little or no prolactin release
clozapine
cutaneous reactions
chlorpromazine
retinal deposits, leukocytosis and leukopenia, and ventricular arrhythmias
thioridazine
agranulocytosis
clozapine
neuroleptics and seizures
neuroleptics decrease seizure threshold
depot preparation for non-compliant patients
fluphenazine and risperidone
used to treat Tourette's and Huntington's
Haloperidol
act at chemreceptor trigger zone
chlorpromazine and haloperidol