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11 Cards in this Set
- Front
- Back
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propothyrouracil blocks...
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the iodonitation of thyroglobulin
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step up from t3 to t4 does what to its potency?
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increases
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going from t4 to t3 does what to its potency
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decreases
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what things down regulate the stimulation of TSH?
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glucocorticoids and growth hormone on anterior pituitary, t4 on hypothalamus and ant. pit.
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average adult dosage of levothyroxine?
childrens? |
1.7 ug/kg/d
children is MORE |
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levothyroxine is converted to what where?
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from t4 to t3 in the TISSUES
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what are the t3 drugs?
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the LIO drugs lio is 3 letters
the LEVO drugs are 4 letters |
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why t4 over t3 drugs?
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t4 drugs are more stable, less toxicity, lower potency
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what are the anti thyroid drugs?
Fire Fighters (anti fire-thyr) |
Fire Fighters are PROS and putting out METH fires with SALT water
methimizole, propythiouracil, sodium iodide |
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what do methimizole and propythiouracil do?
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They inhibit the coupling of iodine and amino acids necessary to produce t4. They also inhibit the conversion of t4 to t3 in the tissues. They are slow at onset because the body needs to go through its existing stores of t4.
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adverse effects of thioamides (methimazole and propylthiouracil)
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rash, arthralgia, agranulucytosis. Since the two drugs are so similar, you cant really use them interchangeably.
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