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21 Cards in this Set
- Front
- Back
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What increases TBG? |
Estrogen, TBG is produced in the liver |
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What drugs are used to replace thyroid hormone? |
Levothyroxine - t4 liothyronine - t3 Liotrix - 4/1 ration of t4/t3 - rarely used |
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What would you use Liothyronine for? |
Myxedema coma therapy short term tsh suppression in patients getting thyroid surgery Patients with deiodinase deficiency |
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When is levothyroxine absorption the highest? |
during fasting state |
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What precautions must you take when tx patients with hypothyroidism |
if they are chronic their heart may be too sensitive to TH Long term t4 could cause bone resorption |
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What is the MOA of thioamides? |
Prevent iodination of tyrosine residues in thyroglobulin. Block coupling They have a slow onset because they accumulate in thyroid gland |
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What is metimazole? |
thioamide 10x potency, used for more rapid achievement of euthyroidism |
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What is (PTU) propylthiouracil? |
thioamide, partialy inhibits peripheral conversion of t4 to t3 -good for thyroid storm -contraindicated for kids and pregnancy |
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What drugs may cause GI upset, macropapular rash, fever, joint pain, and hyperpigmentation? |
thioamides |
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What drug can cause cytotoxic hepatitis? |
PTU |
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What drug can cause cholestatic jaundice? |
Methimazole |
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What does potassium iodide do? |
depresses thyroid fnx by inhibiting release of TH -useful in thryotoxicosis tx -useful for surgery pretreatment -useful to protect against radioactive exposure |
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What drug is used to prophylax against radioactive exposure? |
Potassium Iodide |
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What can cause enlarged salivary glands, and burning in the mouth and throat? |
Potassium Iodide |
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What do you use radioactive Iodine for? |
emits beta particles to destroy thyroid parenchymal cells used to ablate thyroid |
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what can cause aggravated exophthalmos in graves? |
Radioactive Iodine |
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What can you use esmolol for? |
thyroid storm beta blockers are good for rapid hyperthyroid relief If you can't use beta blockers use ccb |
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What does lithium do? |
inhibits TH concentrated in thyroid gland |
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What drug contains a lot of iodine and can thus cause hyperthyroidism? |
Amiodorone |
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What drugs can mitigate exophthalmos in graves? |
Corticosteroids |
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What do corticosteroids do to the thyroid axis? |
inhibit TSH secretion, decrease binding of thyroxine and TBG |
