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3 Cards in this Set
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- Back
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Levothyroxine (T4) & Triiodothyronine
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Thyroid preparations that activate nuclear thyroid receptors and stimulate gene expression and protein synthesis.
Used for hypothyroidism and myxedema. Toxicity: tachycardia, heat intolerance, tremors, arrhythmias. |
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Propylthiouracil
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Inhibits peroxidase, inhibits organification of iodide and coupling of thyroid hormone synthesis and also inhibits 5'-deiodinase which decreases peripheral conversion of T4 to T3.
Used for hyperthyroidism. Toxicity: hepatotoxicity, agranulocytosis. |
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Methimazole
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Inhibits peroxidase, inhibits organification of iodide and coupling of thyroid hormone synthesis.
Used for hyperthyroidism. Toxicity: teratogenic, CI during pregnancy. |
