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10 Cards in this Set
- Front
- Back
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Describe the Synthesis , Storage and Secretion of Hormones |
Active uptake of iodide (stimulated by TSH) Iodide is oxidised to iodine my peroxidase Active transport into lumen of follicle Formation of Mon and di iodinated tyrosine Uptake of thyroglubulin Iodinated tyrosine combines to form T4 and 3 |
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Release of Hormone |
Thyroglobulin carrying T3/4 is taken up via endocytosis into follicle cells Endocytotic vesicles fuse with lysosomds and proteolytic enzymes act on thyroglobulin releasing T3/4 and thyroglobulin inside cell T3/4 enter bloodstream |
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Effects of Thyroid Hormone |
T4 is converted to T3 which acts on nuclear receptor. Receptor associates with DNA leading to mRNA and protein synthesis |
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Hypothyroidism- define symptoms |
Lack of hormone Depressed metabolic rate , co and appetite Lethargy Hashimotos |
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Define the symptoms of hyperthyroidism |
Graves disease (autoimmune) Antibody mimics effects of TSH Increased thyroid stimulation , metabolic rate, appetite and sympathetic activity |
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Name Three Thioureylenes and What They Do |
Propylthiouacil, Methimazole , Carbimazole Inhibits conversion to iodine Prevents iodinated to form T3/4 and conversion of T4 to T3 |
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Catecholamines and Effects |
Adrenal medulla secretes ADR and Na to lesser extent Stimulates release of metabolic fuels - glucose and fatty acids -Mediated by cAMP |
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Adrenocortical Hormones |
Act on nuclear receptors Receptor plus hormone unfolds and binds DNA hormone response element Increase RNA polymerase activity MRNA activity and protein synthesis |
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Mineralocorticoids |
Regulates water and salt Acts on distal renal tube to increase sodium reabsorption Spironolacetone is diuretic (aldersterone antagonist ) Aldesterone receptor complex increases number of sodium channels |
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Glucocorticoids |
Metabolic Antiinflammatory Immunosuppressive effects Inhibits Phospholipase A2 - blocks prostaglandin , leukotrienes and Arachonic acid |
