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22 Cards in this Set
- Front
- Back
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What are the synthetic hormones used to treat hypothyroidism?
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Levothyroxine
Liothyronine Liotrix (combo of the two) |
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What is the preferred treatment of hypothyroidism?
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Levothyroxine
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What is the most appropriate treatment for long-term thyroid hormone replacement?
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Levothyroxine
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What is the most appropriate agent for short-term TSH suppression?
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Liothyronine
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What are the 3 primary anti-thyroid mechanisms?
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1) decrease production of thyroid hormones (goitrogens)
2) decrease tissue response to thyroid hormones 3) destroy gland (surgery or radiation) |
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What are the classes of anti-thyroid drugs?
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Thioamides
Iodides Radioactive iodine |
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What are the actions of goitrogens?
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1) suppress secretion of T3 and T4
2) increase in TSH 3) goiter |
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What is the major drug class used to treat thyrotoxicosis?
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Thioamides (ie propylthiouracil, methimazole)
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What is the preferred Thioamide drug for treatment of thyrotoxicosis in pregnant patients?
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Propylthiouracil
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What is the major action of Thioamides in the treatment of thyrotoxicosis?
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Inhibits thyroidal peroxidase thereby preventing hormone synthesis
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What is the most common adverse effect of Thioamide treatment?
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Maculopapular pruritic rash
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What is the most serious potential reaction of Thioamide treatment?
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Agranulocytosis
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What is the major action of iodide therapy in the treatment of thyrotoxicosis?
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Inhibition of thyroid hormone release
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What are some clinical implications of iodide therapy?
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1) short-term management of thyroid storm
2) preoperative preparation *Iodides are rarely used as monotherapy |
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What is the radioactive iodine isotope used for treating thyrotoxicosis?
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I-131
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What is the basis for therapeutic efficacy of radioactive iodine in the treatment of thyrotoxicosis?
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Beta emission
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What is the mechanism of action of radioactive iodine in the treatment of thyrotoxicosis?
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Thyroid parenchymal destruction
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Radioactive Iodine is contraindicated in which patients?
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Pregnant patients
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What is the rationale behind using adrenergic receptor blockers in the treatment of thyrotoxicosis?
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Reduction of sympathetic manifestations
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Which adrenergic receptor blockers can be used to reduce the sympathetic manifestations of thyrotoxicosis?
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PROPRANOLOL
Beta blockers Guanethidine |
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What components are critical in the treatment of thyroid storm?
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1) manage dehydration
2) propylthiouracil and iodine to block hormone synthesis 3) propranolol to reduce sympathetic manifestations |
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What is the earliest and most important labratory finding in hypothyroidism?
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Increased TSH
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