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7 Cards in this Set
- Front
- Back
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Thyroid Hormone Replacement
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Levothyroxine (T4)
Liothyronine (T3) |
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Hyperthyroidism
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Propylthiouracil
Radioactive Iodine (I 131) Potassium iodide (KI) |
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Levothyroxine
Liothyronine |
Administration: orally, IV for myxedema coma, Levothyroxine - preferred for long-term replacement therapy
pregnancy - higher doses required |
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Radioactive Iodine
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Use: thyrotoxicosis
MOA: damage DNA of thyroid cells -> beta rays SE: destroys thyroid gland, will need levothyroxine replacements CI: Pregnancy & lactation |
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Iodides
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Purpose: hyperthyroidism
MOA: Inhibit hormone release, Inhibit organification, Decrease size and vascularity of the hyperplastic gland SE: Effect is reversible and transient, not used for long term CI: pregnancy --> fetal goiter |
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Propylthiouracil
Methimazole |
Purpose: hyperthyroidism, preferred in pregnancy
MOA: inhibit thyroid peroxidase to block iodine organification and coupling reactions SE: Agranulocytosis; liver probs (PTU) |
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Thyroid Storm
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propranolol/esmolol/Diltiazem
PTU --| T4->T3 Hydrocortisone --| T4->T3 Iodide/Ipodate --| T4->T3 |
