Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
T3
|
active form
|
|
|
T3 action
|
binds to receptor and produces effects by altering gene transcription (slow onset, long lasting)
|
|
|
hypothyroid signs:
|
TSH high
goiter cold interolerance fatigue MYXEDEMA |
|
|
hyperthyroid signs:
|
TSH low
exopthalmus tachycardiac thyrotoxicosis...thyroid storm |
|
|
levothyroxine
|
synthetic T4, converted to T3 in the body, long half life, delayed onset which is good...don't want to overdo it
takes 6 weeks different preps, different activity |
|
|
liothyronine
|
synthetic T3
short half life increase risk for cardiotoxicity |
|
|
TSH
|
thyrotropin
|
|
|
hashimotos
|
antibodies against thyroid tissue
TX: ablation hypothyroidism |
|
|
graves
|
receptor-stimulating antibodies produces against TSH receptor
thyroid neoplasms hyperthyroidism |
|
|
thyroid hormone toxicity
|
resembles thyrotoxicosis (extension effect)
cardiovascular effects (CP-pull med immediately) others hyperthermia in kids osteoporosis in old women |
|
|
thyroidectomy
|
total removal: bad idea, can damage parathyroid and laryngeal nerve, 15% recurrence rate
radioactive iodine (RAI) ablation really good, cheap, eventuall destroys thyroid w/o damaging other things, inital thyrotoxicosis may require tx for 2-6 mo. may need long term thyroid hormone replacement not for preggos |
|
|
methimazole
|
thioamide for hyperthyroidism (blocks thyroid peroxidases)
6 weeks for effects |
|
|
propylthiouricil (PTU)
|
thioamide for hyperthyroidism (blocks thyroid peroxidases)
6 weeks for effects |
|
|
thioamide SE
|
1. rash and fever
2. liver toxicity (PTU especially) 3. leukopenia for agranulocytosis |
|
|
propanolol
|
good for hyperthoridism and antiarrhythmics
blocks the effects of thyroid hormone in the heart inhibits T4 to T3 conversion non-cardioselective! |
|
|
potassium iodide
|
inhibits T3 and T4 release
not really used fast acting so good to use to protect thyroid in radiation emergencies |
|
|
goitrogens
|
lithium, amiodarone
inhibit the release of thyroid hormone...hypothyroidism |
