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5 Cards in this Set
- Front
- Back
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Thymoma: Epidemiology
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- Most common anterior mediastinal tumor (50%)
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Thymoma: Presentation
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- 1/3 are diagnosed incidentally on CXR
- Sx: Chest pain, cough, dysphagia, SVC syndrome, paraneoplastic syndromes |
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Paraneoplastic Syndromes Associated with Thymoma
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Myasthenia Gravis (in 30-45% of patients with thymoma)
Pure Red Cell Aplasia Hypogammaglobulinemia Various vasculitides Other autoimmune disorders RARE IN THYMIC CARCINOMA |
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Thymoma: Work-up
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- Labs: CBC, chemistries, LFTs, BUN/Cr
- AFP and B-hcG in males to rule out germ cell tumor - Chest CT - MRI or PET can be considered - Biopsy: CT-guided core needle, mediastinoscopy or VATS |
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Thymoma Histology
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6 subtypes as defined by WHO. These are of PROGNOSTIC SIGNIFICANCE
A: Medullary thymoma AB: Mixed thymoma B1: Predominantly cortical thymoma B2: Cortical thymoma B3: Thymic carcinoma C: Well-differentiated thymic carcinoma |
