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18 Cards in this Set
- Front
- Back
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what are the characteristics of venous thrombosis?
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fibrin clot associated with blood flow stasis, treated with anti-coagulants
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what are the characteristics of arterial thrombosis?
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platelet clot associated with atherosclerosis, causes ischaemia, treated with antiplatelet drugs
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name the three types of anti-coagulant drugs?
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WAH warfarin Anti-thrombin II independent drugs Heparin |
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what is the mechanism of action of warfarin?
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inhibits coagulation factors, 2, 7, 9 and 10
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what will potentiate the activity of warfarin?
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NSAIDs, drugs that interfere with liver function, liver disease and decreased vitamin K
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what will decrease warfarin activity?
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barbituates, vitamin K and cholestipol
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how does heparin work?
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activates anti-thrombin III, inhibiting coagulation factor 2a and 10a.
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what does LMW heparin inhibit?
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coagulation factor 10
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name an anti-thrombin III drug?
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hirudin, hirugen, bivalirudin
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how does aspirin interfere with platelet function?
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inactivates COX, causing inactivation of platelets
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What are ADP receptor antagonists used to treat?
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congenital bleeding disorders
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name some ADP receptor antagonists?
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(Tickle, tickle, cloppy, pra sugar) ticlopidine, ticagrelor, clopidogrel, prasugral |
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When are antiplatelet drugs used?
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in patients with a risk of MI or who've had an MI, following coronary bypass/angioplasty, following strokes/ischaemia
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name the four types of platelet inhibitors?
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PAPI prostaglandin agonists ADP antagonists phosphodiesterase inhibitor IIb/IIa receptor antagonists |
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What do thrombolysis drugs do?
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promote conversion of plasminogen to plasmin which breaks down fibrin
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how do fibrinolytic thrombolytic drugs work?
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they break down fibrin
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name two types of fibrinolytic drug types:
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streptokinase recombinant TPA |
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how do anti-fibrinolytic thromblytic drugs work?
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they target and inhibit plasminogen activation or plasmin action
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