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26 Cards in this Set

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Thymoma #1 adult mediastinal tumor location and % of total
anterior mediastinum , 20% of total
% benign and malignant tumors in adults
benign - 60%, malignant - 40%
% benign and malignant tumors in children
benign - 50%, malignant - 50%
Mediastinal Tumor Locations in Adults:
adults ant -55%, mid - 20%, post - 25%
Mediastinal Tumor Locations in Children:
children ant -25%, mid - 15%, post - 60%
Anterior Mediastinal Tumor Histology:
thymoma > lymphoma > germ cell tumors > carcinoma
Middle Mediastinal Tumor Histology:
cysts > lymphoma > mesenchymal tumors > carcinoma
Posterior Mediastinal Tumor Histology:
neurogenic tumors > cysts > mesenchymal tumors > endocrine tumors
Thymoma – malignant behavior is determined by
not determined by histologic criteria (cells look benign), but by evidence of invasion
Thymoma % noninvasive vs invasive
2/3 noninvasive, 1/3 invasive
Name of the staging system
MASAOKA STAGING SYSTEM
Stage I
completely encapsulated macroscopically & no microscopic capsular invasion
Stage II-1
macroscopic invasion into surrounding fatty tissue or mediastinal pleura
Stage II-2
microscopic invasion into the capsule
Stage III
macroscopic invasion into neighboring organs (pericardium, great vessels, lung)
stage IVA
pleural or pericardial implants
Stage IVB
lymphogenous or hematogenous mets
myasthenia gravis associated with __ %
50% of cases
edrophonium (Tensilon) tests what receptor
anticholinesterase temporarily improves symptoms
Rate of local recurrence
local recurrence s/p complete resection: may occur 10-20 yr after initial therapy , non-invasive (stage I) - 2%, invasive, no RT (stage II-III) - 30%, invasive, RT (stage II-III) - 5%
5-yr survival
overall 80%, I - 95%, II - 85%, III - 70%, IV - 50%
5-yr survival based on resection
total resection - 85%, subtotal resection - 65%, biopsy - 40%
RT indications:
(1) Masaoka stage II-III invasive thymoma regardless of completeness of resection, (2) definitive treatment for unresectable invasive thymoma, (3) pre-op +/- chemo
RT dose
54-60 Gy
mediastinal germ cell tumor, __ % of all germ cell tumors and __ % of extragonadal germ cell tumors.
2-5% of germ cell tumors, 50-70% of extragonadal germ cell tumors
Mediastinal Germ cell tumors, ___ benign and ___ malignant
benign (2/3) - mature teratoma - 60% and malignant (1/3) pure seminoma 15%, nonseminoma 25%