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5 Cards in this Set

  • Front
  • Back
Thiazide Diuretics
MOA
• work on DCT to block Na+Cl-

SE
• ED
• hypovolemia
• hypokalemia
• hyperuricemia
• hypercalcemia
• dyslipidemia
• hyperglycemia & increased A1C

C/I
• pregnancy- placental hypoperfusion

Facts
• reduced effects when taking NSAIDS
• possible digoxin toxicity
Loop Diuretics
MOA
• work on ascending loop of Henle to block Na+/K+/2Cl-

SE
• hypokalemia
• hyponatremia
• hypoclacemia
• ototoxicity
• GI- N&V, diarrhea, anorexia
K+ Sparing Diuretics
SE
• hyperkalemia when used as monotherapy
ACEIs
MOA
• inhibit ACE in lungs decreased angiotensin II synthesis vasodilation & decreased aldosterone secretion decreased TPR & increased Na+ excretion

SE
• hyponatremia
• cough- doesn’t stimulate kininase, which increases bradykinin, leading to cough
• hyperkalemia
• fever, rashes, taste alterations- due to increased kinin
• angiodema- due to increased kinin
• hypovolemia

C/I
• K+ sparing diuretic
• pregnancy- category X
• renal arterial stenosis- precipitates acute renal failure

Facts
• good for whites when used as montherapy
• 1st line choice in HTN pts w/ diabetes
• good for pts w/ heart failure
ARBs
MOA
• block aldosterone receptors increased Na+ excretion

SE
• hyperkalemia
• hyponatremia

C/I
• pregnancy

Facts
• no effect on bradykinin metabolism (unlike ACEI)
• not as effective in blacks
• good got pts w/ diabetes
• expensive