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5 Cards in this Set
- Front
- Back
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Thiazide Diuretics
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MOA
• work on DCT to block Na+Cl- SE • ED • hypovolemia • hypokalemia • hyperuricemia • hypercalcemia • dyslipidemia • hyperglycemia & increased A1C C/I • pregnancy- placental hypoperfusion Facts • reduced effects when taking NSAIDS • possible digoxin toxicity |
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Loop Diuretics
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MOA
• work on ascending loop of Henle to block Na+/K+/2Cl- SE • hypokalemia • hyponatremia • hypoclacemia • ototoxicity • GI- N&V, diarrhea, anorexia |
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K+ Sparing Diuretics
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SE
• hyperkalemia when used as monotherapy |
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ACEIs
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MOA
• inhibit ACE in lungs decreased angiotensin II synthesis vasodilation & decreased aldosterone secretion decreased TPR & increased Na+ excretion SE • hyponatremia • cough- doesn’t stimulate kininase, which increases bradykinin, leading to cough • hyperkalemia • fever, rashes, taste alterations- due to increased kinin • angiodema- due to increased kinin • hypovolemia C/I • K+ sparing diuretic • pregnancy- category X • renal arterial stenosis- precipitates acute renal failure Facts • good for whites when used as montherapy • 1st line choice in HTN pts w/ diabetes • good for pts w/ heart failure |
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ARBs
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MOA
• block aldosterone receptors increased Na+ excretion SE • hyperkalemia • hyponatremia C/I • pregnancy Facts • no effect on bradykinin metabolism (unlike ACEI) • not as effective in blacks • good got pts w/ diabetes • expensive |
