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17 Cards in this Set
- Front
- Back
|
FORMAT
DRUG PRODRUG (PRO) |
METHOD
PHOS OR NOT DISEASES |
|
|
Antiviral for Herpesviruses
Acyclovir Valacyclovir (pro) |
chain terminator/inhibit DNA poly
Phos by viral TK HSV or VSV |
|
|
Antiviral for Herpesviruses
Penciclovir Famciclovir (pro) |
chain terminator/inhibit DNA poly
Phos by viral TK HSV or VSV or Herpes |
|
|
Antiviral for Herpesviruses
Ganciclovir Valganciclovir |
chain terminator/inhibit DNA poly
Phos by viral TK CMV - esp IC host; significant toxicity, myelosupression |
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|
Antiviral for Herpesviruses
Cidofovir |
inhibit DNA poly
Phos by viral TK CMV - renal toxicity |
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|
Antiviral for Herpesviruses
Foscarnet |
viral DNA poly, reverse transcriptase, RNA poly in vitro
block pyrophos binding site of DNA poly HSV VAV (acyclovir resistant)CMV renal toxicity |
|
|
Antiviral for Herpesviruses
Fomivirsen sodium |
inhibit viral replication; antisense nucleotide complementary to nucleic acid
CMV inflammation, intraocular P RETINITIS IN AIDS (NO EFFECT ON SYSTEMIC DISEASE) |
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|
Respiratory Viruses' Drugs
Ribavirin |
competitive inhibitor of DNA/RNA syn
aerosol RSV - pneumonitis with interferon for Hep B/C USED IN SEVERE DISEASES (MEASALS) |
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|
Respiratory Viruses' Drugs
Amantadine Rimantadine |
prevents uncoating of virus/release of genome
influenza A/Parkinson's reversible CNS effects fewer CNS in rimantadine |
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Respiratory Viruses' Drugs
Zanamavir Oseltamavir |
neuroaminidase inhibitors
influenze A/B prophylactic treatment as well |
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Neucleoside Reverse Transcriptase Inhibitors (NRTIs)
|
comp. inh of reverse transcriptase
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non-nucleotide reverse transcriptase inhibitors (NNRTIs)
|
bind to rev. transcriptase at different site
|
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protease inhibitors
|
HIV proteases
|
|
|
lypodystrophy
|
altered fat distribution
buffalo hump, truncal obesity, facial atrophy |
|
|
Immunomodulators
|
alter immune response (interleukins)
|
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interferons
|
subset of immunomodulators
produced by cells, antivirals |
|
|
interferon alpha
|
Hep B
CNS disorders |
