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37 Cards in this Set
- Front
- Back
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what are the classifications of ED
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psycogenic
organic drug induced |
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performance axiety
relationship problems are examples of what type of ED |
psychogenic
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what are the subclassifications of Organic ED
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neurogenic - impaired nerve conduction
hormonal - hypogonadism, hyperprolactenemia, HPA disorder vasculogenic - decreased blood flow (HTN, DM, trauma, Peyronie's disease) |
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what are some of the drugs that can induce ED
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anticonvulsants
antihypertensive metoclopramide (dopamine antagonist) antidepressants estrogens excessive alcohol cig smoking CNS depressants (BZD, barbituates) antiandrogens (spironolactone) |
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what antihypertensive agents can cause ED
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beta blockers
clonidine methyldopa diuretics |
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what are the risk factors for ED
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HTN
DM smoking chronic alcohol abuse |
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vacuum erection devices are 2nd line but can be used in conjunction with what agent
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Alprostadil
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what are the drugs used to treat ED
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PDE-Inhibitors (sildenafil, vardenafil, tadalafil)
Alprostadil Phentolamine Papaverine |
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what agents are given intraurethral
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alprostadil (MUSE)
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what agents are give intracavernosal
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alprostadil
papaverine phentolamine |
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what agent is also used to treat PAH
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Revatio (Sildenafil)
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what dose does Sildenafil come in
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25
50 100 |
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Jim is 89 years old what dose of Sildenafil should he be started on
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pts >65
25mg |
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what is the SE of PDE inhibitors
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priapism
HA hypotension flushing dyspepsia nasal congestion |
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what agent causes visual problems
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Sildenafil
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what are the drug interactions of PDE-inhibitors
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CYP3A4 inhibitors - ketoconazole
intraconazole (sildenafil) ritonavir indinavir (vardenafil) nitrates CAUTION IF PT ON ALPHA BLOCKER |
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what agents have decreased absorption with fat meals
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sildenafil
vardenafil |
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what are the dose of vardenafil would be given to a geriatric pt
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5
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what agent may cause ECG changes and you should therefore avoid agents that prolong QT
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vardenafil
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if a patient has hepatic impairment what dose of Tadalafil should they get
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max 10 mg
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what PDE-I has no problems with visual disturbances
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tadalafil
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what agent increases the concentration of tadalafil
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ketoconazole
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when administering Nitrates how far apart must they be when giving PDE-I
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sildenafil/vardenafil - 24hrs
tadalafil - 48hrs |
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why is the initial dosing of Alprostadil done at the Dr's office
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risk of syncope and priapism
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what agent is contraindicated if a patient has abnormal penile anatomy
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MUSE (transurethral Alprostadil)
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what are the properties of Papaverine
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monotherapy
OR in combo with: phentolamine of alprostadil |
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what agent is a nonselective alpha blocker
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phentolamine
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under what circumstances is it ok to treat a pt w/ ED with testosterone
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if they have HYPOGONADISM
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what agent CAN'T BE USED AS MONOTHERAPY
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phentolamine
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what must you screen for before treating a pt with testosterone
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BPH
prostate cancer |
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what SSRI will not have ED adverse effects
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venlafaxine
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what antidepressants in particular cause ED
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paroxetine
sertraline fluoxetine |
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what hormonal issues can cause ED
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hypogonadism
hyperprolactenemia |
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how do dopamine antagonist cause ED
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increased prolactin levels
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what dose of Sildenafil would be given for hepatic impairment
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25 mg
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at what CrCl would you give 25 mg Sildenafil
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CrCl < 30
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what are the CYP3A4 inhibitors
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ketoconazole
itraconazole ritonavir indinavir |
