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18 Cards in this Set
- Front
- Back
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Synthesized in epithelial cells of proximal tubules and exerts local diuretic and natriuretic effects.
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Dopamine
"Agonists" pg 6 |
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• Main effect is beta-1 mediated increase in myocardial contractility
• More prominent inotropic than chronotropic and low doses (could be used after cardiac surgery) |
Dobutamine
"Agonists" Pg 6-7 |
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D1 agonist and moderate α-2 agonist (less importantly, sometimes used in treatment in hypertension).
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fenoldopam
"Agonists" Pg 6 |
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(less importantly, sometimes considered slightly more selective for β-1
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Dobutamine
Ag pg6 |
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What are known for treatment of asthma (what class of drug)? What is the problem with the receptor it works on?
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β-2 agonists; unwanted tachycardia while treating the asthma (β-1 effect)
Ag Pg 7 |
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Fill in the blank: In β-2 Selective Agonists, selectivity is _____________________.
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dose-dependent
Ag pg 7 |
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Drug used in delaying labor?
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tolbutaline (only mentioned in G&G) or ritodrine
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Name two LABAs, how long they last, what they are often paired with, and what receptor they act on.
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Salmeterol and Formoterol, both have duration of >12 hrs
S: with fluticasone F: budesonide Both are beta-2 agonists |
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What is the drug designed specifically for uterine relaxation? What class is it in?
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Ritodrine
B-2 selective agonist (otherwise acts like others in the class) |
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What type of drug is formoterol? What is the related drug? What is the difference between them?
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•Beta-2 selective agonist; Long acting indicated for nighttime asthma
•Aformoterol •Aformoterol is one of the two enantiomers of formoterol. It is 2x more potent than the racemic, and is indicated for long-term treatment of COPD (and asthma) |
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What is Neo-Synephrine? Class? Indications?
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Phenylepherine; alpha-1 agonist
• Indicated for Nasal decongestant, opthalmic formulations, and parenteral for shock/hypotension |
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Mephentermine
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•mixed acting alpha-1 agonist
•indirect sympthomimetic •parenteral injection for hypotension caused by spinal anesthesia •NE release may increase heart rate |
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Metaraminol
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•mixed acting alpha-1 agonist
•indirect sympathomimetic •Parenteral for hypotension, PAT (peraxysmal atrial tachycardia) |
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Uses of alpha-1 agonists (5)? Contraindications (2)?
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Uses:
•hypotension •postural hypotension •shock •nasal decongestion •mydriasis Contraindication •cardiac disease •hypertension |
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Which alpha-1 receptor agonist is a prodrug? What does it treat?
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midodrine; it treats patients with autonomic deficiency and postural hypotension (it induces hypertension)
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Clonidine
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Alpha-2 agonist (in CNS): decreases sympathetic outflow. used in hypertension, withdrawl, anesthetic adjunct, epidural analgesia, hot flashes from menopause
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Which two alpha-2 agonists that we discussed would be good for treating glaucoma?
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apraclonidine & bromonidine
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In which class is tizanidine? What is it used to treat?
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It is an alpha-2 agonist with some properties similar to clonidine. It is a muscle relaxant used to treat cerebral and spinal injury
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