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8 Cards in this Set
- Front
- Back
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Why does drug distribution, metabolism, and excretion differ in neonates and infants?
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their organ systems are not fully developed, such as liver function and the blood-brain barrier
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What are some drugs that are eliminated faster in children than in adults?
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clindamycin, valproic acid, ethosuximide, and theophylline
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What is the meaning of additive effects?
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when 2 drugs with similar pharmacological actions result in an effect equal to the sum of the individual effects
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What is synergism?
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when 2 drugs with similar pharmacological actions produce greater effects than the sum of individual effects
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What is potentiation?
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when one drug with no inherent activity of its own increases the activity of another drug that produces an effect
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What is displacement?
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a drug bound to a plasma protein is removed when another drug of greater binding potential binds to the same protein
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What is inhibition?
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when a drug blocks the activity of metabolic enzymes in the liver
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What is induction?
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when a drug causes more metabolic enzymes to be produced, thus increasing the metabolic activity
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