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8 Cards in this Set

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  • Back
Why does drug distribution, metabolism, and excretion differ in neonates and infants?
their organ systems are not fully developed, such as liver function and the blood-brain barrier
What are some drugs that are eliminated faster in children than in adults?
clindamycin, valproic acid, ethosuximide, and theophylline
What is the meaning of additive effects?
when 2 drugs with similar pharmacological actions result in an effect equal to the sum of the individual effects
What is synergism?
when 2 drugs with similar pharmacological actions produce greater effects than the sum of individual effects
What is potentiation?
when one drug with no inherent activity of its own increases the activity of another drug that produces an effect
What is displacement?
a drug bound to a plasma protein is removed when another drug of greater binding potential binds to the same protein
What is inhibition?
when a drug blocks the activity of metabolic enzymes in the liver
What is induction?
when a drug causes more metabolic enzymes to be produced, thus increasing the metabolic activity