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16 Cards in this Set

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1676
Leeuwenhoek recorded the first accurate observations of the major groups of microorganisms using a simple microscope.
1798
Jenner uses cowpox 'vaccinations. To prevent smallpox.
1850-1860
Pasteur, Cohn & Lister contributed yo the germ theory (details in handout)
1869
Miescher discovered nucleic acids.
1875
Cohn founded bacterial systematics
1876
Koch demonstrated that Bacillus anthracis caused anthrax (the first bacterial pathogen of animals)
1880
Pasteur (studies w/ chicken cholera) developed the concept of Attenuation (reduced virulence) as a general approach to the production of the vaccine.
1881
Developed solid media method for pure culture isolation.---- Led to the use of Petri dish and Agar as a solidifying agent.
1882
Metchnikoff discovered Phagocytosis [Nobel Prize, 1908]
1184
Koch's Postulated was discovered. [Noble Prize 1905]
Koch's Postulates
1) recover same microorganism from infected but not from uninfected individual.
2) Make pure culture of microorganism
3) Infect Healthy individual with pure culture-----repeat step 1
1888
Beijerinck was the first to isolate nitrogen-fixing bacteria
1890 (I)
Winogradsky discovered sulfur & nitrifying bacteria.
1890 (II)
Beijerinck &Winogradsky developed enrichment culture techniques and demonstrated the importance of bacteria in biological cycling
1890 (III)
Behring & Kitasato developed diphtheria antitoxin using inactivated diphtheria toxin [Noble Prize 1901]
1892
Ivanowsk provided evidence that tobacco mosaic disease was caused by filterable virus---- passed through chamberland's filters