The Generation Of Lymphocyte Ag Receptors (Ch 4)

Front 1

Ab diversity is generated by 4 main processes

Back 1

Before Ag exposure and happens at random:
1. Combinatorial diversity (VDJ choices)
2. Junctional diversity (imprecise joining)
3. H and L combination

After Ag exposure
4. Somatic hypermutation

Front 2

Combinatorial diversity

Back 2

- Before Ag exposure
- The multiple inherited gene segments are used in different combinations

Front 3

Junctional diversity

Back 3

- Before Ag exposure
- Variable addition and subtraction of nucleotides at the junctions between gene segments contributes to diversity on the 3rd hypervariable region.

Front 4

H and L combination

Back 4

- Before Ag exposure

Front 5

somatic hypermutation

Back 5

- Occurs after B cell has been activated.
- randomly introduces SNT substitutions at a high rate throughout the rearranged V regions of heavy and light chain genes.
- Eventually results in affinity maturation.

Front 6

Affinity maturation

Back 6

The process of evolution in which variant Ig's generated in a random manner are subjected to selection for improved binding to a pathogen.

Front 7

What is the survival advantage provided by having multiple genes and multiple alleles for each MHC gene?

Back 7

This makes your offspring to be immunology strong.