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183 Cards in this Set
- Front
- Back
- 3rd side (hint)
name the 4 components of the CVS |
1 blood 2 heart 3 circulatory sys 4 lymphatic sys |
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define hemolymph |
components of blood |
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name the 4 functions of blood |
1 transport 2 regulation 3 defence agst pathogens 4 blood clotting |
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name the 4 things that blood transports |
1 gases in solution 2 nutrients 3 waste products 4 hormones and enzymes |
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give 2 example for gases in sol transported by blood |
O2 carried from lungs to tissues CO2 carried from tissues to lungs |
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give 3 examples of nutrients transported by blood |
AAs, glucose, fatty acids carried fr GI tract to liver and other parts of body |
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where are waste products carried to and what happens there? |
liver and kidneys - metabolised or excreted |
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hormones and enzymes are carried from the ___ to the ___ ___ |
glands to the target tissues |
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blood helps to regulate 3 things. what are they? |
1 vol and osmotic pressure 2 body temp 3 acid/base balance |
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how does blood fight agst pathogens? |
WBCs and other immune compounds |
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name the 2 things that blood clotting prevents |
excessive blood loss entry of pathogens through wounds |
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explain osmotic/oncotic pressure |
without the ions and proteins in the blood vessels in the blood vessels, the water would osmose out of the blood vessels and into the cells, usually in the subcut zones (this is known as ascites) |
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what is the pH range of blood? |
pH 7.35 to 7.45 |
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blood contains ___ to ___% plasma, which contains about ___% water |
55 to 70, 90 |
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what does plasma contain? (___ being ___ from ___ to ___) |
substances being transported from one part of the body to another |
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give 6 examples of these substances |
1 nutrients 2 waste products 3 hormones 4 enzymes 5 antibodies 6 antigens |
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blood also contains mineral salts. name the 3 functions of these mineral salts (the mineral salts don't necessarily serve all 3 functions) |
1 essential for other organ systems 2 act as buffers of pH 3 maintain osmotic balance |
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give 6 examples of these mineral salts |
sodium Na(+) chloride Cl(-) potassium K(+) calcium Ca(2+) magnesium Mg(2+) bicarbonate HCO3(-) |
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name the 4 types of plasma proteins |
1 albumin 2 fibrinogen 3 prothrombin 4 immunoglobins |
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state the function of albumin |
albumin prevents water in blood vessels from "leaking" out into extracellular spaces (loss of water -> dcr in blood vol _> dcr in blood pressure) |
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state the function of fibrinogen and prothrombin (and what they form) |
involved in clotting mechanism fibrinogen forms fibrin prothrombin forms thrombin |
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what is so special about a mammal's erythrocytes compared to its other cells? |
erythrocytes are biconcave discs with no nuclei |
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explain the pale region in the erythrocyte shown in the diagram |
erythrocytes have a pallor which is thinner and therefore contains less haemoglobin to stain red |
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what is haemoglobin and why does it make erythrocytes red? |
it is a pigment in the erythrocytes which binds to oxygen it contains a heme group which contains iron and thus gives the molecule its red colour |
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under a microscope, how can one tell apart an erythrocyte from other cells? |
erythrocytes are red and they are the most numerous type of cell |
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what does "haemoglobin has a high affinity for oxygen" mean? |
haemoglobin takes up oxygen v readily |
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oxygen bonds to haemoglobin to form ___ |
oxyhaemoglobin |
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explain the Bohr effect |
in areas of CO2 conc, affinity of Hb to O2 is reduced -> Hb readily gives up its O2 in respiring tissues where O2 is needed most |
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why is CO poisoning v lethal? |
Hb preferentially bonds to CO to form carboxyhaemoglobin |
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define erythropoiesis |
the process of making erythrocytes. old RBCs are replaced by new ones from bone marrow in a never-ending cycle |
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what happens to old RBCs after they die? |
broken down to recycle iron from the heme OR heme is converted into bilirubin |
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what is bilirubin? |
a yellow-green substance found in bile |
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which organ is esp active in removal of RBCs? (and what 3 types of RBCs does it remove?) |
spleen old, dead, defective |
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name the 2 differences b/w erythrocytes and leukocytes (WBCs) |
1 leukocytes are bigger than erythrocytes when mature 2 leukocytes contain nuclei |
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name the 2 types of leukocytes |
1 granulocytes 2 agranulocytes |
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name the 3 types of granulocytes and what makes them so special (comp to agranulocytes in terms of their nuclei) |
1 neutrophils 2 eosinophils 3 basophils
they are polymorphonuclear (nuclei are segmented) |
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name the 2 types of agranulocytes and one distinguishing feature of each one |
1 lymphocytes 2 monocytes
lymphocytes have a single rounded nucleus monocytes are pleomorphic (varying in shape) and have non-segmented irregular nuclei |
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this leukocyte contains granules that stain neither with blue alkaline stain nor red acid stain |
neutrophil |
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a mature neutrophil can have ___ to ___ nuclear segments joined by a strand of ___ |
2 to 5, chromatin |
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-neutrophil released from bone marrow bef maturing -horseshoe shaped nucleus without segmentation |
band neutrophil |
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neutrophils contain ___ which have ___ ___ that can destroy pathogens and they can respond ___ --> they are ___ |
lysosomes; digestive enzymes; quickly; phagocytes |
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eosinophils have granules that stain which dye what colour? |
acid dye red |
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what role does a eosinophil play and how does it combat antigens? |
mediates allergic rxns also effective agst parasitic worm & protozoa infections combats antigens by phagocytosis (eats them) |
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basophils contain granules that stain which dye what colour? |
alkaline dye blue (B-asophil, B-asic dye, B-lue stain) |
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what is the shape of a eosinophil's nucleus? |
spectacle- shaped |
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presence of eosinophils usually indicates 2 things. what are they? |
1 parasitic infections 2 allergic rxns |
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basophils are the ___ observed blood cells in a blood smear |
least |
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what is the only diff b/w basophils and mast cells? |
basophils are involved in humoral immunity whereas mast cells are involved in cell-mediated immunity |
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define "humoral immunity" |
immunity that takes place in the bloodstream |
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monocytes are the ___ most abundant type of WBC and also the ___ type of WBC. they are involved in ___ immunity |
3rd; largest; humoral |
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where can monocytes be found and how do they combat antigens? |
"filter" organs (liver, spleen, lungs, lymph nodes) they combat antigens by phagocytosis and sometimes form macrophages |
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name the 3 differences between T-cells and B-cells |
1 T-cells mature in the thymus while B-cells mature in the bone marrow 2 T-cells take part in cell-mediated immunity while B-cells take part in humoral immunity 3 T-cells are for general immunity whereas B-cells recognise and target specific antigens |
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platelets/thrombocytes are actually ___ of ___ released from giant ___ in the bone marrow |
fragments of cytoplasm; megakaryocytes |
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what purpose do platelets serve? |
they are an essential part of haemostasis (blood clotting) |
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define "cell-mediated immunity" |
immunity that takes place in cells |
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what role does the basophil play and how does it combat antigens? |
initiates allergic rxns degranulates |
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explain the 1st step of haemostasis (hint) |
platelets stick to damaged blood vessel and each other to form a haemostatic plug, then release an enzyme called thromboplastin |
involves platelets |
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explain the 2nd step of haemostasis (hint) |
in the presence of thromboplastin and Ca(2+) ions, prothrombin is converted to thrombin |
presence of ___ and ___ p->t |
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explain the 3rd step of haemostasis (hint) |
thrombin converts fibrinogen to fibrin which forms a meshwork to trap blood cells and forms a clot -> seals blood vessels and forms a scab over time |
f->f meshwork ___ blood vessels and forms ___ |
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where is prothrombin formed and what is needed for the production of prothrombin? |
liver; vit K |
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the heart is enclosed in a double-layered sac called the ___ |
pericardium (peri -> around, cardium -> heart) |
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name the space b/w the 2 serous layers of the pericardium and the fluid it contains |
pericardial cavity, pericardial fluid |
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name the thin membrane covering the whole internal surface of the heart |
endocardium |
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name the muscular layer b/w the epicardium and the endocardium |
myocardium |
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the R and L atria are divided by the ___ ___ |
interatrial septum |
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the R and L ventricles are divided by the ___ ___ |
interventricular septum |
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what is the function of the two sets of valves within the chambers of the heart? |
they prevent backflow from the ventricles to the atria |
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- lies b/w the R atrium and R ventricle - consists of 3 cusps/flaps |
R atrioventricular valve/tricuspid valve |
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- lies b/w the L atrium and ventricle - consists of 2 cusps/flaps |
L atrioventricular/bicuspid/mitral valve |
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free edges of the AV valves are attached to ___ muscles of the walls of the ___ by fibrous threads called ___ ___ |
papillary; ventricles; chordae tendinae |
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the AV valves close when the ___ are full to prevent ___ of ___ into the ___ |
ventricles; full; backflow; blood; atria |
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the ___ ___ prevent the valves from ___ as blood is pressed agst them when ventricles ___ |
chordae tendinae; erverting (turning inside out); contract |
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___ of the AV valves produces the "___" sound |
closure; lub |
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name the sets of valves at the base of the major vessels leaving the ventricles |
semilunar valves |
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what is the function of the semilunar valves? |
prevent backflow of blood from vessels back into ventricles |
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the semilunar valves are composed of ___ ___-___ shaped cusps |
3 half-moon (thus the name semilunar) |
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___ of the semilunar valves produces the "___" sound |
closure; dub |
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how many types of semilunar valves are there and what are they? |
2; pulmonary/pulmonic valve; aortic valve |
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where is the pulmonary valve located? |
lies at the base of the pulmonary artery as it leaves the R ventricle |
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where is the aortic valve located? |
lies at the base of the aorta as it leaves the L ventricle |
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mammals and birds have a double circulatory sys. this means that the R atrium and ventricle are resp for the pulmonary circulation of ___ blood, and... (next card) |
pulmonary; deO2ated (from R a&v to lungs then back to L a&v) |
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the L atrium and ventricle are resp for the ___ circulation of ___ blood |
systemic; O2ated (from L a&v to body then back to R a&v) |
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deO2ated blood from the head region and thoracic limbs flow back to heart via ___ ___ ___ to __ atrium |
cranial vena cava; R |
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deO2ated from trunk and pelvic limbs flow back to heart via ___ ___ ___ to __ atrium |
caudal vena cava; R |
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the R ventricle empties blood into the ___ ___, from which this deO2ated blood enters the lungs and picks up O2. from the lungs, the O2ated blood is carried in the ___ ___ to the L atrium |
pulmonary artery; pulmonary veins |
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the L ventricle pumps the O2ated blood through the ___, which distributes the blood to the body tissues via a network of ___ and ___ |
arteries and capis |
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when the atria contract, is there a corresponding contraction/relaxation of the ventricles? when the ventricles contract, is there a corresponding contraction/relaxation of the atria? |
no yes (relaxation) |
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the period of contraction is termed ___ while the period of relaxation is termed ___ |
systole; diastole (the Cat is Scared of the Red Dog) |
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define "cardiac output" |
vol of blood pumped by heart per min |
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define "stroke vol" |
vol pumped by heart in one contraction |
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define "heart rate" |
no. of contractions per min |
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therefore give the word eqn of cardiac output |
cardiac output = stroke volume x heart rate |
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what is resp for initiating and coordinating the heartbeat? |
the conduction sys |
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name the pacemaker of the heart |
sinoatrial node |
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the sinoatrial node is an area of ___ ___ ___ cells in the wall of the ___ ___, near its junction with the ___ ___ ___ |
modified cardiac muscle R atrium Cr VC |
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the impulse to contract starts at the sinoatrial node and the ___ of ___ spreads across the ___ -- this is known as atrial ___ |
wave of contraction; atria; atrial systole |
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since the myocardium of the ventricles is separated from the atria by the fibrous skeleton, the impulse from the atria must pass thru a specialised group of cardiac muscle cells in the ___ ___ |
atrioventricular node |
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the atrioventricular node sends the impulse along the ___ of ___, a specialised bundle of fibres which runs down the ___ ___ |
bundle of His; interventricular septum |
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the bundle of His then divides into the R and L branches which spread out into the 2 ___ |
ventricles |
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the branches of the bundle connect with a specialised network called the ___ ___ which carry the impulse thru the ___ ___ |
Purkinje fibres; ventricular muscles |
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as the wave of contraction spreads upwards towards the ventricles, blood is pushed through the ___ ___ and the ___ -- this is known as ventricular |
pulmonary artery; aorta; ventricular systole |
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name the band of muscle running across the lumen of the R ventricle and containing the R branch of the bundle of His fibres that provides a shortcut for the impulse |
trabecula septomarginalis |
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what is the purpose of the trabecula septomarginalis? |
provides a shortcut for impulse --> ensures that all muscle cells of ventricles contract simultaneously |
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majority of arteries carry ___ blood exc the ___ artery which transports ___ blood to the ___ |
O2ated; pulmonary; deO2ated; lungs |
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name the 3 layers of an arterial wall (from deep to superficial) |
- tunica intima - tunica media - tunica adventitia |
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what does the tunica intima consist of? |
endothelial lining continuous throughout circulatory sys |
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what does the tunica media consist of? |
smooth muscle and elastic tissue |
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what does the tunica adventitia consist of? |
collagen and elastic fibres |
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the elastic nature of the arterial walls allows them to ___ or ___ and enables them to withstand blood under high ___ as it ___ the heart |
dilate; constrict; pressure; leaves |
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as the arteries enter the tissues, they give off side or ___ vessels which link up with each other to form a network (aka ___) |
collateral; anastomosis |
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what is the purpose of the anastomoses? |
if any of the branches gets obstructed, the blood has an alt route thru the tissue and the cells will still rcv O2 and nutrients |
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some organs (eg. brain, heart, kidney) lack anastomoses but inst have ___ ___ |
end arteries |
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end arteries form a similar pattern to the branches of a tree (branch but never join up) --> prevents dmg by sudden ___ in ___ ___ |
drop in blood pressure |
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if an end artery is occluded, (eg. by a blood clot) the result could be ___ |
fatal |
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as the distributing arteries branch off in the tissues, they become ___ and ___ and are called ___ |
smaller; narrower; arterioles |
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veins have relatively ___ walls and usually carry ___ blood back to the heart under ___ pressure, exc the ___ vein which transports ___ blood to the heart |
thin; deO2ated; low; pulmonary; O2ated |
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veins have similar wall structure to arteries but have fewer ___ ___ and ___ ___ |
smooth muscle; elastic fibres |
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some veins carry blood agst the pull of ___ and have ___ ___ to prevent backflow of blood. ___ of surrounding muscles also helps to squeeze blood along veins |
gravity; semilunar valves; contraction |
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what are smaller veins known as? |
venules |
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capis consist of a single layer of ___ cells |
endothelial |
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exchange of ___, uptake of ___ and removal of ___ ___ take place at capis in tissues |
gases; nutrients; waste products |
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name the network of capis extending bw the arterioles and venules within tissues |
capi bed |
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name the 2 major arteries of systemic circulation |
1 aorta 2 coronary arteries |
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name the 3 segments of the aorta |
1 ascending aorta 2 aortic arch 3 descending aorta |
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ascending aorta angles ___ as it leaves the __ ___ (hint) |
dorsocranially; L ventricle |
ascends ___-___ (two directions) |
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the ascending aorta then continues as the ___ ___, then turns ___ as the ___ ___, which is divided into the ___ and ___ sections |
aortic arch; caudally; descending aorta; thoracic and abdominal |
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name the 5 branches that the abdo aorta gives off and state if they are paired or unpaired |
1 unpaired celiac artery 2 unpaired cranial mesenteric artery 3 unpaired caudal mesenteric artery 4 paired ovarian/testicular arteries 5 paired renal arteries |
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what does the celiac artery supply? |
stomach, spleen, liver |
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what does the Cr mesenteric artery supply? |
sml intestine |
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what does the Cd mesenteric artery supply? |
lrg intestine |
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what do the ovarian/testicular arteries supply? |
female/male gonads respectively (ovaries/testicles) |
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what do the renal arteries supply? |
kidneys |
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abdo aorta terminates to become the ___ ___ which supplies the ___ |
Cd artery; tail |
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the coronary arteries branch off the ___ to provide blood supply to the ___ cells
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aorta; cardiac |
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the coronary arteries run in ___ on the surface of the heart tgt with corresponding ___ ___ |
grooves; coronary veins |
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name the 4 major veins of systemic circulation |
1 Cr VC 2 Cd VC 3 coronary veins 4 hepatic portal sys |
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the Cr VC returns deO2ated blood fr the ___, ___ and ___ to the heart and receives blood from the ___ veins and the ___ veins |
head, neck, forelimbs; jugular; subclavian |
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the jugular veins run down either side of the ___ surface of the ___ in the ___ ___ and drain the ___ |
ventral; neck; jugular furrow; head |
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the subclavian veins collect blood from the veins of the ___, the main ones being the ___ vein from the deeper tissues and the ___ vein from the superficial tissues |
forelimbs; brachial; cephalic (Big Dog Chases Snakes) |
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the Cd VC returns deO2ated blood from the ___ region, ___ and ___ ___ |
pelvic region, hindlimbs, abdo viscera |
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the coronary veins run in the cardiac grooves tgt with the coronary arteries and they join to form the ___ ___ which then empties into the ___ ___ |
coronary sinus; R atrium |
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name the artery that leads to the liver and its corresponding vein |
1 hepatic artery 2 hepatic portal vein |
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the hepatic portal vein carries blood loaded with ___ from the ___ ___ to the liver, where they will be ___ |
nutrients; digestive tract; metabolised |
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the blood within the hepatic portal sys passes thru 2 capi beds bef returning to the heart - one is in the ___ ___ ___ ___ ___ and the other is in the ___ |
organs in the digestive tract; liver |
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the blood in the liver ultimately drains into the ___ ___ which join the ___ ___ ___ |
hepatic veins; Cd VC |
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the L and R common carotid arteries carry O2ated blood to the ___ |
brain |
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the L and R subclavian arteries carry O2ated blood to the L and R ___ |
forelimbs |
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the L and R iliac arteries supply O2ated blood to the ___ |
hindlimbs |
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the brachiocephalic trunk extends ___ from the aorta and supplies the L and R ___ ___ arteries but only supplies the ___ ___ artery |
cranially; common carotid; R subclavian |
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the Cd artery supplies O2ated blood to the ___ |
tail |
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the L and R ext and int jugular veins carry deO2ated blood from the ___ back to the heart |
brain |
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the azygous vein carries deO2ated blood from the ___/___ ___ |
abdo/chest walls |
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during ___ or pregnancy, the ___ of the dam carries out roles that are later performed by the ___, ___ and ___ ___ |
gestation; placenta; lungs; kidneys; digestive tract |
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the placenta provides ___ and ___ and removes ___ ___ |
oxygen; nutrients; waste products |
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the umbilical vein carries ___ blood and ___ ___ from the placenta to the foetus, passing to the ___ ___ |
oxygenated; metabolised nutrients; foetal liver |
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since the foetal liver is not functional, the ___ ___ shunts blood from the umbilical v directly to the foetal ___ ___ ___ |
ductus venosus; Cd VC |
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the umbilical arteries carry ___ blood and ___ ___ fr the foetus back to the placenta and into the ___ ___ of the dam |
deoxygenated; waste products; systemic circulation |
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since foetal lungs are also not functional, the ___ ___ shunts blood from the ___ ___ directly into the ___, bypassing the lungs |
ductus arteriosus; pulmonary artery; aorta |
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the ductus arteriosus closes at birth to become the ___ ___ |
ligamentum arteriosus |
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name the other opening that bypasses the lungs and lies between the R and L atria to shunt blood fr R side to L side of heart |
foramen ovale |
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at birth, the foramen ovale closes and forms a remnant called the ___ ___ |
fossa ovalis |
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the lymphatic sys is resp for returning the ___ ___ ___ that has leaked out of the ___ to the ___ ___ |
excess tissue fluid; capis; circulating blood |
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the fluid of the lymphatic sys is called ___ and is sim to ___ but w/o the ___ ___ ___ |
lymph; plasma; larger plasma proteins |
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lymph contains more ___ than are present in blood |
lymphocytes |
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one function of the lymphatic sys is to ___ ___ and other ___ ___ fr the ___ in specialised ___ ___ known as ___ ___ |
remove bacteria; foreign bodies; lymph; filtering stations; lymph nodes |
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another function is to transport the products of ___ ___ and the ___-___ ___ from the ___ of the ___ ___ to the circulation (hint) |
fat digestion; fat-soluble vits; lacteals; small intestine |
fat |
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name the 7 components of the lymphatic sys |
1 lymphatic capis 2 lymphatic vessels 3 lymphatic ducts 4 lymph nodes 5 spleen 6 thymus 7 tonsils |
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lymphatic capis are the ___ of the lymphatic vessels. they are ___-___ ___ tubes which form ___ within the ___ |
thinnest; thin-walled delicate; networks; tissues |
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lymphatic capis merge to form larger lymphatic vessels, which have sim structure to ___ and possess numerous closely spaced ___ |
veins; valves |
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lymph flow is mainly ___ and relies on the ___ of surrounding muscles to move the lymph along |
passive; contraction |
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the lymphatic vessels enter the larger lymphatic ducts which drain the lymph into ___ ___ leading to the ___ |
blood vessels; heart |
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the lymph nodes are ___-shaped masses of ___ tissue situated at intervals along the ___ ___. lymphatic vessels enter and leave the node |
bean-shaped; lymphoid; lymphatic vessels |
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___ ___ and ___ are trapped within the ___ of the lymph node and are ___ by the ___ ___ |
foreign particles; bacteria; meshwork; phagocytosed; phagocytic cells |
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lymph nodes can be ___ (this is known as ___) which commonly indicates an ___ of the ___ ___ |
enlarged; lymphadenopathy; infection; drainage region |
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name the 5 palpable lymph nodes and where they reside |
1 submandibular - edge of angle of jaw 2 parotid - just Cd to temporomandibular joint 3 prescapular - 2 on each side lying just Cr to shoulder joint 4 inguinal - 2 on each side bw thigh and abdo wall, dorsal to mammary glands/penis 5 popliteal - within gastrocnemius muscle Cd to stifle joint |
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the spleen is the ___ of the lymphoid organs and is closely attached to the ___ |
largest; stomach |
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the spleen is also a ___ organ, but isn't essential for life and can be removed |
haemopoietic |
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the spleen acts as a ___ for ___, ___ and ___ |
reservoir; lymphocytes; erythrocytes; platelets |
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the spleen is also resp for the ___ of worn out RBCs - the phagocytic cells engulf and destroy the erythrocytes but preserve their ___ ___ for reuse in ___ ___ (hint) |
destruction; iron content; haemoglobin synthesis |
last 2 blanks: which component of blood contains iron? |
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spleen is also resp for removal of ___ ___ fr circulation |
particulate matter |
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the thymus produces __-___ that give rise to ___-___ ___ ___ and thus is of great imptce to young animals as it begins to ___ at the time of ___ and eventually completely disappears |
T-cells; cell-mediated immune response; regress; puberty |
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the tonsils form a ___ of ___ ___ ard the junction of the ___ with the ___ ___ |
ring; lymphoid tissue; pharynx; oral cavity |
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the tonsils act as the first line of defence agst microbes which enter the ___ |
mouth |
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