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20 Cards in this Set
- Front
- Back
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What is the backbone of TG?
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Glycerol
- from glycerol-3-P |
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Whare are FA stored as?
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Triglycerides!! dont be an idiot
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How are Free FA trasnported from Adipose tissue?
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The FA are bound to Albumin to get wherever they are going to be BETAoxidized
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In what form are FA transported TO adipose?
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They are transported as TG component of LIPOPROTEINS!
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Can TG cross the Plasma membrane?
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NO
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What are the 3 types of lipases?
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Pancreatic Lipase
LipoProtein Lipase Adipose (hormone sensitive) Lipase |
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What lipase(s) are present in the Fed/Fasted States?
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FED state= Pancreatic and LipProtein LIPASES
FASTED= Adipose (Hormone Sensitive) LIpase |
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What does Pancreatic lipase do?
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Breaks down dietary TG to free fatty acids and monoacyl glycerol
FED STATE |
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What does Lipoprotein Lipase do?
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Breaks down lipprotein TG to free FA and GLycerol
FED STATE |
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What does Adipose (Horomone Sensitive) Lipase do?
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Breaks down Adipose TG to free FA and glycerol
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What do the products of the Pancreatic Lipase used for?
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the free FA and monoacylglycerol are used to synthesize Lipoprotein (Chylomicron) TG
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What are the products of Lipoprotein Lipase used for
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The free FA and glycerol is used by the adipocytes to synthesize Adipocyte TG
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What are the products of Adipose (Hormone Sensitive) Lipase used for?
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the free FA leave the adipocytes bound to albumin and transported thru the blood stream
- They will enter into B-ox cells and enter their mitochondria to be catabolized |
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What hormone is the Adipose (hormone sensitive) lipase sensitive to?
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Well, Adipose Lipase is in the fasted state
- So that means the hormone would have to be GLUCAGON |
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What happened to the glycerol from all 3 of the lipases' products??
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It goes to the liver
- Phosphorylates into Glycerol-3-P - This occurs via Glucokinase (remember bc we are in the liver!!) |
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What happens to the GLycerol in the liver during FED state
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- its catabolized for energy via Glycolysis
- It can be rephos and used for Hepatic TG synthesis |
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What happens to the GLycerol in the liver during FASTED state?
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in FASTED state ALL glycerol is converted to glucose via GLUCONEOGENESIS
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How is Pancreatic Lipase Activity Controlled?
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It is controlled by the amount of TG injested
- Food ingestion leads to pancreatic secretion of digestive enzymes |
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How is Lipoprotein LIpase Controlled?
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-LPL is controlled via Insulin
This is obvious b/c LPL is a FED state Lipase |
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How is Adipose (hormone sensitive) Lipase controlled?
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- GLUCAGON and also epinephrine
- remember, bc APL is active in the FASTED state - Hence, Fat TG are needed in a fast or an emergency |
