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6 Cards in this Set

  • Front
  • Back
Types of tetracycline
Demecocycline (fr. Streptomyces)
Tetracycline, oxytetracycline, doxycycline, minocycline (synthetic)
Mechanism of action
Inhibition of protein synthesis by competing with tRNA for the A site on the ribosome. Requires active transport into bacterial cells
What is spectrum?
Very wide
G + / G-, Mycoplasma, Rickettsia, Chlamydia, some spirochetes,
and protozoa
Spectrum contd.

Minocyclin
N. meningitidis (nasal carriers)
Spectrum contd

Cross BBB
No
Spectrum contd

Resistance
Resistance is common, plasmid mediated