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6 Cards in this Set
- Front
- Back
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Types of tetracycline
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Demecocycline (fr. Streptomyces)
Tetracycline, oxytetracycline, doxycycline, minocycline (synthetic) |
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Mechanism of action
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Inhibition of protein synthesis by competing with tRNA for the A site on the ribosome. Requires active transport into bacterial cells
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What is spectrum?
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Very wide
G + / G-, Mycoplasma, Rickettsia, Chlamydia, some spirochetes, and protozoa |
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Spectrum contd.
Minocyclin |
N. meningitidis (nasal carriers)
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Spectrum contd
Cross BBB |
No
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Spectrum contd
Resistance |
Resistance is common, plasmid mediated
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