Tetracycline

Front 1

Tetracycline drug

Back 1

doxycycline

Front 2

tetracycline spectrum/bacterio___

Back 2

broad spectrum (gram +, gram -, atypical bacteria)

bacteriostatic

Front 3

tetracycline mechanism

Back 3

bacterial protein synthesis inhibitor

Front 4

tetracycline mechanism: binds ___ which inhibits ___ binding to __ site

Back 4

30S

aminoacyl tRNA

A site

Front 5

tetracycline selectivity requires accumulation in ___ by ___

Back 5

bacterial cell

active drug transporter

Front 6

tetracycline kinetics:

1. absorption inhibited by ____

2. compared to tetracycline, doxycycline has higher: ___, clearance by ___, and a ____ t1/2

3. plasma concentrations affected by ____

Back 6

1. cationic metal ions

2. oral F (.77 compared to .95), hepatic P450 metabolism, longer t1/2

3. liver enzyme inducing agents

Front 7

tetracycline incorpoirates into developing ___

___ possible

contraindicated in ___ and ___

Back 7

teeth/bone

superinfections

pregnant, children

Front 8

drug interactions of tetracycline (2)

Back 8

antacids, hepatic microsomal enzyme inducers

Front 9

uses of tetracycline (ALPP)

Back 9

acne

lyme disease

peptic ulcer disease

periodontal disease

Front 10

tetracycline's utility as broad spectrum agents reduced by ___

Back 10

wide spread resistance

Front 11

chloramphenicol is a ___ spectrum drug and bacterio___

Back 11

broad

bacteriostatic

Front 12

chloramphenicol binds ____ subunit and inhibits ___ activity

Back 12

50S

ribosomal peptidyltransferase

Front 13

some inhibitory effects of chloramphenicol reported on human ___ protein synthesis (not as selective as tetracycline)

Back 13

mitochondrial protein synthesis

Front 14

adverse effects of chloramphenicol

Back 14

aplastic anemia, an idiosyncratic (Rare, unpredicatable) toxicity; life threatning

Front 15

risk is _____ (greater/less) than benefits for trivial infections. therefore, use chloramphenicol for ___ infections only (ex: 2)

Back 15

greater

life threatning

typhoid fever, H. flu meningitis

Front 16

aminoglycoside drug name

Back 16

gentamicin

Front 17

genamicin is ___ spectrum and bacterio____

Back 17

narrow

bacteriocidal

Front 18

genamicin best coverage of ___ with seaker activity of ___

Back 18

gram - aerobes

gram + aerobes

NONE with anaerobes or atypicals

Front 19

genamicin is a bacterial ___ inhibitor

Back 19

bacterial synthesis protein inhibitor

Front 20

genamicin mechanism: binds ___ and has 3 effects:

1. freezes protein synthesis at ____

2. premature ___

3. causes a.a. ____

Back 20

30S

1. initiation complex

2. termination

3. substitutions

Front 21

genamicin's protein synthesis inhibitory effect requires accumulation of drug in organism to ___ levels

bacteria use ___ dependent transporter to accumulate drug in cell.

can human cells do this?

Back 21

high

oxygen-dependent

no

Front 22

genamicin are large, ___, ____ drugs and therefore cannot pass through ___.

oral? IV? required for systemic effects

___ excretion unchanged

T1/2 ___ in renal insufficiency

Back 22

polar, cationic

membranes

Injection required

kidney

increased

Front 23

2 toxicities from genamicin

Back 23

ototoxicity and nephrotoxicity

Front 24

genamicin's toxicity is predictable from ____ and occurs more frequently in ___ insufficiency

Back 24

plasma drug concentration

renal

Front 25

____ required with continuous use of genamicin

Back 25

therapeutic drug monitoring

Front 26

uses of genamicin

Back 26

serious systemic gram - bacilli infections

extracellular only

Front 27

aminoglycosides' neomycin is similar to gentamicin except its use is ___ only

Back 27

topical due to high toxicity

Front 28

use of neomycin

Back 28

gut sterilization prior to bowel surgery

one of the active agents in neosporin topical ointment