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11 Cards in this Set
- Front
- Back
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2 natural tetracyclines
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chlortetracycline and oxytetracycline
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semisynthetic tetracycline
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tetracycline, demclocycline, methacycline, doxycycline, minocycline
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MOA of tetracycline
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enter via active mediated prevents the binding of aminoacyl- tRNA to mRNA by binding to 30S reversibly inhibiting protein synthesis
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tetracycline G+ aerobic spectrum
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G+ aerobes- streptococcus, corynebacterium, erysipelothrix rhusiopathiae, listeria monocytogenes
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pharmacokinetics of tetracycline
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dairy products decrease absorption normally absorbed well orally. chelated by Ca, Mg, Fe, and Al
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doxycycline and minocycline
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highly lipid soluble, highly absorbed.
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kidney friendly
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doxycycline because its excreted through the bile good for patients with renal failure
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side- effects
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overgrowth of clostridium, entrapement in esophagus, stricture in cats, binds to teeth turning them brown, inhibits long bone growth, nephrotoxicity, hepatotoxicity, photosensitivity, hypotension, arrhythmia; sudden death in horses
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bacterial resistance
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changing the binding site
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formulations of oxytetracycline
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propylene glycol for IM and IV, povidone for IM only, 2- pyrrolidone for long acting preparation for IM only
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formulations of doxycyline
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hyclate and monohydrate for oral,
hycalte for IV not used in horses |
