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30 Cards in this Set

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What are the specific ways innate immunity protects?
complement lysis
NK cell lysis
Macrophage lysis
Inferferon protection
What are the specific ways acquired immunity protects?
AB production
cytotoxic T cells
Antiviral cytokines made by T helpers - INF G and tumor necrosis factor
What are the cellular components of innate?
NK
Mast
Mac
Dendritic
What are the humoral components of innate?
Complement
INF A/B
Acute phase proteins
Cytokines
How do interferons protect?
Bind to receptor stimulating enzyme production - stop transcription/translation and another one that inhibits uncoating
OR
Alter membrane blocking penetration
What are ways thae interferons directly aument immune response?
Phagocytosis
Cytokine production by T
NK and CTL
What class do NK cells recognize?
MHC 1
What do NK cells produce?
IL-2
INF G
What does IL-2 do?
Increase T cell proliferation
What do INF G do?
Increase Mac phagocytosis
What are C-onc?
genes that encode for protein and their normal cell function is to control cell growth
What is a viral-onc?
was a c-onc or protooncogene and then it was picked up during virus infection
What are oncoproteins?
proteins encoded by c-onc to act as:
Growth factors
receptors
transcription factors
What are the fuction of pRB and p53?
Master breaks, they stop the cell cycle at G1
What does p53 do?
Binds to cyclin CDK complexes stopping transcription
What are the proteins that papillomaviruses use to block tumor supressor?
E5-E7
What proteins do Adenoviruses use?
E1A
E1B
Define protooncogene.
Normal gene that can become an oncogene
What are viral oncogenes?
Retroviral oncogenes, c-oncs that were highjacked by the cell during replication
List the DNA cancer causing viruses.
Hepadna
Herpes
Pov
Papilloma
Polyoma
Adeno
What cells produce INF A?
Leukocytes
What cells produce INF B?
Fibroblasts
What must cells have to be receptive to INF?
95 kDA receptor
What level does oligonucleotide synthetase work at?
mRNA stopping protein translation
How does protein kinase induced by INF work?
Initiates eLf-2, no protein synthesis
Characterize the specificity of INF.
Wide virus
Narrow host
When is MLV used as an INF inducer?
When disease outbreak of unknown etiology
What are the clinical applications of INF?
Topical use in respiratory
Prophylactic/therapeutic
Cancer TX
Where are INF produced?
At infection site
Do interferons interact with the virus?
NO