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30 Cards in this Set
- Front
- Back
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What are the specific ways innate immunity protects?
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complement lysis
NK cell lysis Macrophage lysis Inferferon protection |
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What are the specific ways acquired immunity protects?
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AB production
cytotoxic T cells Antiviral cytokines made by T helpers - INF G and tumor necrosis factor |
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What are the cellular components of innate?
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NK
Mast Mac Dendritic |
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What are the humoral components of innate?
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Complement
INF A/B Acute phase proteins Cytokines |
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How do interferons protect?
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Bind to receptor stimulating enzyme production - stop transcription/translation and another one that inhibits uncoating
OR Alter membrane blocking penetration |
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What are ways thae interferons directly aument immune response?
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Phagocytosis
Cytokine production by T NK and CTL |
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What class do NK cells recognize?
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MHC 1
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What do NK cells produce?
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IL-2
INF G |
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What does IL-2 do?
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Increase T cell proliferation
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What do INF G do?
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Increase Mac phagocytosis
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What are C-onc?
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genes that encode for protein and their normal cell function is to control cell growth
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What is a viral-onc?
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was a c-onc or protooncogene and then it was picked up during virus infection
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What are oncoproteins?
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proteins encoded by c-onc to act as:
Growth factors receptors transcription factors |
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What are the fuction of pRB and p53?
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Master breaks, they stop the cell cycle at G1
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What does p53 do?
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Binds to cyclin CDK complexes stopping transcription
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What are the proteins that papillomaviruses use to block tumor supressor?
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E5-E7
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What proteins do Adenoviruses use?
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E1A
E1B |
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Define protooncogene.
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Normal gene that can become an oncogene
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What are viral oncogenes?
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Retroviral oncogenes, c-oncs that were highjacked by the cell during replication
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List the DNA cancer causing viruses.
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Hepadna
Herpes Pov Papilloma Polyoma Adeno |
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What cells produce INF A?
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Leukocytes
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What cells produce INF B?
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Fibroblasts
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What must cells have to be receptive to INF?
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95 kDA receptor
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What level does oligonucleotide synthetase work at?
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mRNA stopping protein translation
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How does protein kinase induced by INF work?
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Initiates eLf-2, no protein synthesis
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Characterize the specificity of INF.
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Wide virus
Narrow host |
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When is MLV used as an INF inducer?
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When disease outbreak of unknown etiology
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What are the clinical applications of INF?
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Topical use in respiratory
Prophylactic/therapeutic Cancer TX |
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Where are INF produced?
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At infection site
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Do interferons interact with the virus?
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NO
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