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17 Cards in this Set
- Front
- Back
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intitial phase of therapy in TB
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1. INH (300 mg/day) for 8 wks
2. Rifampin (600 mg/day)8 wks 3. Pyrazinamide (PZA) (25 mg/kg/day up to 2 g/day) 8 wks 4. Ethambutol (15 mg/kg/day) 8 wks 5. pyridoxine (10-25 mg/day) -if isolate reported susceptible to INH and Rifampin, stop PZA and ethambutol. |
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Continuation Phase of therapy in TB (No pulmonary cavities and smear negative after 2 months of therapy)
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1. INH for 26 wks
2. Rifampin for 26 wks 3. Pyridoxine 26 wks |
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therapy for TB with cavities present or cultures positive after 2 months
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1. INH for 9-12 months
2. Rifampin for 9 months 3. Pyrazinamide for first 2 months 4. ethambutol for 2 months 5. pyridoxine for 9 months *therapy is same for disseminated TB, TB meningitis, osteomyelitis, or TB in children |
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Therapy for INH resistant TB
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1. Rifampin + ethambutol + PZA + Gatifloxacin or Levofloxacin for 6-9 months
2. pts who cannot take PZA (liver disease or hyperuricemia) take Rifampin + ethambutol for 12 months; streptomycin is alternative for ethambutol |
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Therapy for INH and rifampin resistant TB
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use at least 4 active drugs--
for 18-24 months or 12-18 months after last positive culture |
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intitial phase of therapy in TB
|
1. INH (300 mg/day) for 8 wks
2. Rifampin (600 mg/day)8 wks 3. Pyrazinamide (PZA) (25 mg/kg/day up to 2 g/day) 8 wks 4. Ethambutol (15 mg/kg/day) 8 wks 5. pyridoxine (10-25 mg/day) -if isolate reported susceptible to INH and Rifampin, stop PZA and ethambutol. |
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Continuation Phase of therapy in TB (No pulmonary cavities and smear negative after 2 months of therapy)
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1. INH for 26 wks
2. Rifampin for 26 wks 3. Pyridoxine 26 wks |
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therapy for TB with cavities present or cultures positive after 2 months
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1. INH for 9-12 months
2. Rifampin for 9 months 3. Pyrazinamide for first 2 months 4. ethambutol for 2 months 5. pyridoxine for 9 months *therapy is same for disseminated TB, TB meningitis, osteomyelitis, or TB in children |
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Therapy for INH resistant TB
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1. Rifampin + ethambutol + PZA + Gatifloxacin or Levofloxacin for 6-9 months
2. pts who cannot take PZA (liver disease or hyperuricemia) take Rifampin + ethambutol for 12 months; streptomycin is alternative for ethambutol |
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Therapy for INH and rifampin resistant TB
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use at least 4 active drugs--
for 18-24 months or 12-18 months after last positive culture |
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TB in pregnancy
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INH + Rifampin + ethambutol for 9 months. all cross placenta and appear not to be teratogenic. DO NOT USE PZA.
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treatment of minimal TB
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IHN susceptible:
1. INH for 9 months; if abnormal xray, treat 12 months DOT For INH resistant: 1. Rifampin for 4 months; DO NOT use rifampin + PZA for treatment of minimal disease due to cases of lethal hepatotoxicity |
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TB prophylaxis
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Multidrug resistant TB:
PZA + Ethambutol + Levofloxacin + an Aminoglycoside for 18-24 months |
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treatment of listeria monocytogenes
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Penicillin or ampicllin alone or in combo with gentamycin
Early antibiotic treatment of infected pregnant women can increase chances of having healthy child. No vaccine. |
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Pasteurella treatment
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penicillin
treat septic arthritis with joint drainage and antimicrobials. |
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treatment of brucella
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Spontaneous resolution: CMI important for clearance—activated macrophages required; Brucella replicates within normal macrophages.
-control of disease in livestock with vaccine (none against suis or canis) -avoidance of unpasteurized dairy products -doxycycline combined with rifampin for at least 6 wks -TMP-SMX + rifampin for pregnant women or children under 8 yrs -No human vaccine available |
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tularemia treatment
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Streptomycin drug of choice, but toxicity issues may exist.
Gentamycin – acceptable alternative. |
