Test 2 Chemical Path Of Adrenal Cortex

Front 1

cortisol levels

Back 1

depend on time of day, increased in acutely ill, surgery; high estrogen states cause elveated total because CBG is high (pregnancy estrogen Rx or BC; androgen Rx)

Front 2

data on cortiosl from clinical labs are

Back 2

total levels

Front 3

salivary cortisol concentrations are

Back 3

10 times lower than serum cortisol, so the assay performs well alt low concentrations

Front 4

hormones in saliva

Back 4

stable for a few dys

Front 5

when to take salivary cortisol

Back 5

midnight and around 8 a.m. and on two separate evenings between 2300 and 2500 avoid smoking or licorice.. And be awre of shift workers

Front 6

why does urinary free cortisol work

Back 6

the high percentage of total cortisol that is bound to CBG is not filtered but in cushing sthat amount is exceeded.

Front 7

problems in urinary free cortisol

Back 7

collectino of the sample 24 hrs.must avoid losts of h20 and all glucocorticoids, including skin creams

Front 8

urinary 17-OH-CS

Back 8

no longer used iven better plasma an durinary free cortisol used to be the standard to eval hypoadrenocorticism and cushing syndrome with acth

Front 9

can you diagnose endocrine malfunction based on basal homrone levels

Back 9

rarely

Front 10

does dexamethasone interfere with cortisol radio immunoassays?

Back 10

no

Front 11

normal subject low dose dexa

Back 11

if given at 1.p.m will eliminate rise in acth that occurs in the early morning hours

Front 12

in cusings syndrome day 2 cortisol will be greater than 10micrograms/dl

Front 13

false negatives in dexamethosone supression test

Back 13

when metab is slow(drugs inhibiting cp450) resulting in higher leveks and greater acth fall

Front 14

false positives in dexamethosone suppression.

Back 14

hospitalized and chronically ill , depressed patients, and drugs that induce cp450 344… phenobarbital, phenytoind, carbamazepine, primidone, rifampin, pioglitazone

Front 15

patients with cushing DISEASE

Back 15

will supress cortisol to levels less than 50% of baseline on high dose dexamethasone (img at 11p.m.)

Front 16

two day high dose dexamethasone

Back 16

original high dose now overnight

Front 17

metyrapoine

Back 17

determination of cortisol reserve… inhiits cortisol synthesis affects crh

Front 18

hypoglycemia

Back 18

pitiutary and adrenal reserve affects CRH

Front 19

acth and cortisol are ___ hormoens in glucose homeostatis

Back 19

both counterregulatory

Front 20

cosyntropin

Back 20

synthetic alpha 1-24 acth.. Acth stimulation test.. Peak response should exceed 20micgram/dl

Front 21

metyrapone inhibits

Back 21

11B hydroxylase is inhibited resulting in in the adrenal secreting 11 deoxycortisol (substance S)

Front 22

if metyrapone test is + need ACTH stim to confrim findings

Front 23

crh infusion and acth

Back 23

acth exaggerated in addison, absent in hypopituitarism, dlayde in hypothalamic, good for cushings too

Front 24

what's incrased in 21 hydroxylase deficinecy

Back 24

DHAE

Front 25

cyp11 deficincy

Back 25

build up of 11 deoxycortisone and doxycortisol thus low cortisone and cortisol

Front 26

cyp17

Back 26

buildup of prog and preg thus low cortisol and dhea

Front 27

abiguous genitalia in m, htn, and hypokalmic alakalosis

Back 27

cyp17, low dhea and high corticosterone (HTN) and alkalosis from high aldo and high Na cuasing k to leak

Front 28

doc and cortisone are

Back 28

mineralocorticoids

Front 29

ambiguous genitalia in F and HTN

Back 29

cyp11 deficiency, aldo is normal, cortisone and cortisol low,,,, more dhea

Front 30

ambigious gentitalia in f and salt loss

Back 30

cyp21 deficiency prog and 17 hydroxyprog build up leading to more dhea, low aldo, coricosterone and cortisol

Front 31

aldo in cyp 17

Back 31

increasesd hypokalemic alkalosis

Front 32

aldo in cyp deficiency

Back 32

11 normal, 17 high 21 low

Front 33

hypokalemic alkalosis

Back 33

cyp 17 hihg aldo

Front 34

htn in cyp deficincy

Back 34

low cyp 21 high cyp 11 and cyp 17.. Increased DOC in 11 and corticosterone in cyp 17

Front 35

thorn test

Back 35

acth stim test cosytropin

Front 36

slow acth stim response

Back 36

abnormal axis not intact obtain plasma acth to distinguish 1 from 2

Front 37

CONTENT VALIDITY

Back 37

Degree to which an interview, test, or other selection device measures the knowledge, skills, abilities, or other qualifications that are part of the job; An instrument