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15 Cards in this Set
- Front
- Back
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What covalent modification promotes recruitment of RanGAP1 to the nuclear pore complex? |
SUMO Protein |
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What covalent modification promotes recruitment of Ras to the inner cell membrane to activate Ras-signalling? |
Farnesylation |
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What do you name a saturated 18 carbon fatty acid? How about if it has 1 double bond. What about 2 double bonds? |
Octadecanoic Acid! Octadecandienoic Acid Octadecatrienoic Acid |
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How do we number fatty acids? |
Carboxy terminus is 1! |
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How do we denote the position of a trans double bond between C9 and C10 on a C18 lipid and another Cis between C12 and C13? |
Trans-delta 9 Cis-delta 12 Octadecadienoic Acid! |
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Where is the Omega carbon? |
Carbon at the end of the tail |
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What does a choline headgroup look like? |
RO(CH2)2N(CH3)3 + |
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What does cardiolipid look like? |
2 Phospholipid groups attached to terminal oxygens on a glycerol chain |
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What is a cerebroside? |
Fatty acyl unit N-linked to a sphingosine Sugar unit O-linked to a sphingosine |
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What do Conical, Inverted Conical, and Cylindrical lipid shapes organize into? |
Cylinders make Lipid Bilayers Inverted Cones make micelles Cones make cubes |
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How does an integral membrane protein differ from a peripheral membrane protein? |
Integral proteins have a transmembrane region while peripheral do not |
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How do Monotopic and Bitopic membrane proteins differ? |
Monotopic has no membrane spanning domain while bitopic does |
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How do you make type 2 membrane protein crystals? |
Solubilize the protein in detergent This allows for crystal contacts to form between the soluble portions of the protein |
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Where is cardiolipin found? |
Mitochondria! |
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What are 3 common membrane anchors? |
S-palmitoylcysteine GPI C-terminal S-farnesylcysteine methyl ester |
