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195 Cards in this Set
- Front
- Back
8 cervical
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top most part of spine
-C1 & C2- Head and Neck -C3 &C4- Diaphram -C5- Deltoids, Biceps -C6- wrist extenders -C7-Tricepts -C8- Hand |
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12 thoracic
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second from the top spine
-T1-Hand -T2-T7- Chest Muscles -T8-T11- Abdominal Muscles -T12- leg muscles |
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5 lumbar
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third most from the top of the spine
-L1-L5- Leg muscles |
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5 sacral
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bottom most segment of the spine
-S1-S3- Bowel, Bladder -S4-S5- Sexual function |
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Basal Ganglia can be seen in which view
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Horizontal section, Coronal (transverse) section
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Layer 1 of cortex has
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few cell bodies
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Layers II, III, V, and VI of cortex
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consists primarily of cell bodies or pyramidal neurons
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peripheral nervous system
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1) cranial nerves
2) spinal nerves 3) autonomic nervous system |
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how does the signal get from the eye to visual cortex
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travels via cranial nerve II the optic nerve
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LGN
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subnucleus of the thalamus
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eye-->optic nerve (tract)-->LGN-->visual cortex
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visual information processing
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12 cranial nerves
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7 sensory
5 motor |
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5 motor cranial nerves
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-3 (III) Oculomotor
-4 (IV) Trochlear -6 (VI) Abducens -11 (XI) Spinal accessory -12 (XII) Hypoglossal |
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7 sensory cranial nerves
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-1 (I) Olfactory
-2 (II) Optic -5 (V) trigeminal -7 (VII) Facial -8 (VIII) Vestibulocochlear -9 (IX) Glossopharyngeal -10 (X) Vagus |
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Trigeminal nerve
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-cranial nerve V
-has both sensory and motor components |
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Vagus nerve
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-cranial nerve X innervates much of the periphery
-does all of the projecting below (trigenial neuralgia-constant pain, shooting pain)if severed can't feel anything on the contralateral side of the body |
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cranial nerves
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most cranial nerves impact just the head and neck
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hypothalamus is made of a bunch of different subnuclei
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paraventricular nucleus, superoptic nucleus contain endocrine neurons which project down into the posterior pituitary and relaease on the capillary system
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oxytocin stimulates
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uterine contractions, which triggers milk letdown, facilitates social bonds (released during orgasm)
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Vasopressin (AVP) acts on
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kidney to reduce urine output (water conservation), increases blood pressure
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anterior pituitary gland
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-neurosecretary cells in hypothalamus produce releasing hormones are secreted into hypothalmic pituitary portal system, releasing hormones circulate to anterior pituitary endocrine cells to stimulate release of tropic hormones, which circulate to target tissues to release target hormone
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neuroendocrine cell bodies in the hypothalamus produce releasing hormones
-neruons terminate at the |
mdian eminence- a region above the pituitary stalk that contains blood vessels the hypophyseal portal system
-releasing hormones travel through these vessels and are released in the anterior pituitary, where there are additional hormone producing cells, which produce tropic hormones, which are released into the bloodstream and travel to and regulate endocrine glands throughout the body |
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hypothalamic pituitary adrenal axis
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critical for stress...flight or fight response
-under stressful conditions the hypothalamus produces corticotropin releasing hormone (CRH) which is released into the capillaries in the median eminence -CRH travels to the anterior pituitary and causes the release of a tropic hormone (adrenocorticotropic hormone (ACTH)-released into the blood and travels to adrenal gland which releases cortisol, which feeds back to the anterior pituitary and decreases further ACTH release (negative feedback important for hormone regulation) |
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in prairie voles, blockade of either dopamine or oxytocin receptors w/in the nucleus accumbens
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blocks mating-induced partner preferences which shows that these receptors are necessary for this behavior
-activation of dopamine or oxytoxcin receptors can facilitate partner preference formation -shows that activation of these receptors is sufficient to produce this behavior |
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protein and amine hormones bind to
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metabotropic receptors on the cell surface
-activate G-protein mediated second messenger cascades -fast acting (seconds to minutes) (still slow compared to neurotransmitters like glutamate (miliseconds) |
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steroid hormones
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-pass through cell membranes
-bind receptors located inside the cell -form a complex and binds DNA -then acts as a transcription factor -takes hours to take effect...takes time to make new protein |
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second messengers, like cAMP, can have immediate effects on proteins in the cell making
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protein and amine hormone effects rapid (but still slower than ion channels)
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similarities btw. neurons and endocrine cells
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1)both produce, store, and release chemical messages
2)neurons and endocrine cells are directed to release chemical messages by other cells 3)neurotransmitters and hormones act on receptor proteins; some using second messengers |
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differences btw. neurons and endocrine cells
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1) neural is direct, hormones are diffuse
2)many neural signals are fast, hormonal messages are slow. |
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main endocrine glands
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1)pineal gland: reproductive maturation; body rhythms
2)pituitary gland/anterior pituitary/posterior pituitary:/hormone secretion by thyroid, adrenal cortex, and gonads; growth/water balance; salt balance 3)thyroid: growth and develoopment, metabolic rate 4)adrenal glands/adrenal cortex/adrenal medulla: /Salt and carbohydrate metabolism;inflammatory reactions, emotional arousal 5)pancreas: sugar metablolism 6)Gonads: body development; maintenance of reproductive organs in adults |
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the pituitary gland is a
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major endocrine gland
-two distinct components: anterior pituitary and posterior pituitary (completely separate in function) |
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oxytoxin and vasopressin neurons in the hypothalamus project
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to the posterior pituitary and are called hypothalamic
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nongenomic effects
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hormone binds at membrane through second messenger (ex: estrogen receptors on the membrane)
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neurosecretory cells extand all the way into the
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posterior pituitary and terminate on capillaries and action potentials release Oxytoxin (OT) and Vasopressin (AVP) into blood stream
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hormones traditionally define traveling through the blood, there is also
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neuroendocrine signaling that occurs w/in the brain (or from brain to pituitary)
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autocrine communication
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hormone released by a cell which then affects its own activity
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paracrine communication
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hormone released by a cell to affect nearby target cells
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endocrine communication
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hormone released into bloodstream to act on distal target tissues
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pheromones
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hormonal signaling from one individual to another
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allomones
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hormonal signaling btw. species
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principles of hormone action
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1)slow, gradual action that outlasts hormonal signal
2)changes intensity or probability of behavior rather than turning behavior on or off 3) hormones produced in small amts. often secreted in bursts 4) hormones affect metabolic processes in most cells 5)hormones affect only those cells that have receptors for the hormone |
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protein hormones
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(strings of amino acids)-ex: vasopressin
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Amine hormones
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single amino acids e.g. thyroid hormone
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steroid hormones
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four carbon rings e.g., testosterone, estrogen
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norepinephrine receptors
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are metabotropic
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large population of acetylcholine containing neurons are located in the
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basal forebrain (including the diagonal band and nucleus basalis)
-project to hippocampus, amygdala, and cortex (important for attention and learning) -lost in Alzheimers |
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curare blocks ____ receptors (it is an _____)=paralysis
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nicotinic, antagonist
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all drugs of abuse increase dopamine in
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the nucleus accumbens
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microdialysis
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probe lowered into the dopamine region, porous membrane, artificial CSP pumped in and out and up a collection vial and inside the membrane conc. of dopamine is 0, extracellular space lots of dopamine moves into collection tube and gets pumped out and you can measure conc. of dopamine
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THC -lipid-endocannabinoids
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act on CB1 and CB2receptors (both metabotropic)
-endogenous ligand is a lipid like substance called anandamide -not stored in vessicles, transport then deactivated by enzyme |
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CB1 receptors are on the terminals that release
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glutamate, GABA, acetylcholine and monoamines
-anadamide is co-released -binds CB1 receptors on the presynaptic terminals, which opens K+ channels which hyperpolarized the presynaptic neuron, reduces action potential frequency |
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soluble gases (nitric oxide) produced from
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arginine by nitric oxide synthase and is released as soon as it is produced (not stored in vesicles)
-does not activate a membrane bound receptor -enters cells and activates enzyme which produces a 2nd messenger (cGMP) |
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hormone
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chemical of communication that is secreted into bloodstream and carried to distinct target tissues
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organs in the body that make and secrete hormones
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endocrine glands
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amino acid neurotransmitters
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GABA and Glutamate, and a wide variety of peptide neurotransmitters
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nicotinic receptor
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referring to cholinergic receptors that respond to nicotine as well as to acetycholine
-ionotropic -excitatory -muscles have nicotinic receptors |
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muscarinic receptor
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referring to cholinergic receptors that respond to the chemical muscarine as well as to acetylcholine
-G-protein coupled (metabotropic) receptors -can be excitatory or inhibitory |
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striatum
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the caudate nucleus and putamen together
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dopamine
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metabotropic receptors
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glutamate
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metabotropic and ionotropic receptors
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gaba, acetylcholine
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ionotropic (fast changes in membrane potential)
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g proteins can be
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stimulatory or inhibitory
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stimulatory increase
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second messenger (CAMP- bind open ion channel) (allows amplification of the signal thousand second messenger per moleciule of bound dopamine)
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medium spiny neuron is a
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GABA containing cell
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cortex contains pyramidal cells which contain glutamate and it's job is
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put glutamate onto these meidium spiny neurons, which project caudally and have a GABA signal, they are constantly inhibiting caudally
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medium spiny neurons express either
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D1 or D2 type dopamine receptors (both metabotropic either have stimulatory or inhibitory over on CAMP system
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glutamate is major _____ on GABA receptors and chloride is the major _____on inhibitory GABA receptors
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depolarizer, hyperpolarizer
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output of these striatal cells is a
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gabaergic projection
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agonist is a drug (GABA receptor)
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that activates a receptor (relaxes you ex: xanax, benzodiazaphenes, rophies)
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D1 receptor
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stimulatory G protein (alpha binds adenelocyclase increases CAMP)
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D2 receptor
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reduces action of adenelocyclase and decreases the amt. of CAMP in the cell
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dopamine releases at
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the neck of the spine
-act more as a volume transmitter (not only acts in synaptic cleft but also escape and bind dopamine receptors outside of the synapse |
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Glutamate only binds receptors in
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the synaptic cleft
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serotonin receptors are
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both ionotropic and metabotropic
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dopamine neurons are in the midbrain in the
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ventral tegmentum area (VTA) and substantia nigra
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VTA dopamine neurons project to the
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nucleus encumbens (w/in NE neuron it's projecting to is GABergic neuron)
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substancia nigra dopamine neurons project to
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more dorsal striatum
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molecule binding the receptor is the
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ligand, produced w/in the body (endogenous ligands)
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ionotropic receptors directly control
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ion channels (when ligand binds, channel opens and ions flow across the membrane into the cell)-ligand gated channel
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metabotropic (involves metabolic energy) receptors ligand binds and then indirectly
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opens ion channels through activation of G-proteins (slow, metabotropic receptors)
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gabergic neuron also receives glutamate projections from
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hippocampus, amydala, prefrontal cortex
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gabergic medium spiny neuron (cells of the striatum) receive dopamine and glutamate projections which work together to modulate
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activity of these gaba cells
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G protein consists of
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three subunits (alphe, beta, gama)
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alpha subunit of G protein either
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binds and opens an ion channel or binds an enzyme (such as adenylate cyclase) which produces a second messenger (cAMP), which can then bind and open ion channels
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sensory info sent to brain (peripheral) once it gets to brain, neural processing is called
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encoding
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range fractionization
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different cells respond to different intensities
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initial burth of activity
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phasic
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constant firing of a cell which is a stable firing
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tonic
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motor neurons never send inhibitions to muscle
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only excite, to inhibit system, must dumb inhibitory signal to level of neuron
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proprioception
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sense of your body's position in space
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suplementary motor area
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lesions here means patients cannot initiate movement
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extrapyramidal system
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engage the spinal cord through reticulospinal tract of rubrospinal tract
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rubrospinal is initiated (originates at)
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red nucleus dorsal to VTA strong projections from red nucleus to motor neurons in the spinal cord
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reticulospinal tract
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originates in the reticular formation
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basal ganglia receives dense dopamine innervation
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substantia nigra projections to dorsal striatum very important for mvemet
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learning of behaviors occur in
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basal ganglia
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apraxia
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results from stroke in parietal or frontal cortex
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parkinson's and huntingtons disease disorders of
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basal ganglia
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three different cranial nerves involved in taste
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facial, glossopharyngeal, and vagus
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G protein involved in taste
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gustducin
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mutation in T1R2 prevents perception of
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sweet
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glomeruli
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are in olfactory bulb
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proceptive
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advertising that you are ready to mate
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signal transduction
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process of turning environmental information into sodium channels being open and action potentials occuring
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primary sensory cortex receives
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direct projections from the sensory organ or sensory portions of thalamus
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secondary sensory cortex receives direct projections from
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primary sensory cortex
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area of the brain responding to physical pain
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cingulate cortex
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trpv1 capsaicin - high enough temp causes c fiber to fire action potential
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trpv1 located on c fibers
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even higher temp Trp2 receptors
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adelta fibers not mylinated
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sensing pain in thumb
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reaches spinal cord synapse decussation at spine release glutamate and peptide transmitter called substance p in dorsal horn
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pariaqueductal gray
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opiate receptors activated here through release of endorphins brain kicks into gear to reduce pain as well as get away from it releases opioids which alleviate pain
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proceptive
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advertising that you are ready to mate
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signal transduction
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process of turning environmental information into sodium channels being open and action potentials occuring
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primary sensory cortex receives
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direct projections from the sensory organ or sensory portions of thalamus
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secondary sensory cortex receives direct projections from
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primary sensory cortex
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area of the brain responding to physical pain
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cingulate cortex
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traveling of noxious stimuli signal to brain is called
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nociception
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trpv1 capsaicin - high enough temp causes c fiber to fire action potential
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trpv1 located on c fibers
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even higher temp Trp2 receptors
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adelta fibers not mylinated
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sensing pain in thumb
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reaches spinal cord synapse decussation at spine release glutamate and peptide transmitter called substance p in dorsal horn
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pariaqueductal gray
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opiate receptors activated here through release of endorphins brain kicks into gear to reduce pain as well as get away from it releases opioids which alleviate pain
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sexual dimorphic nucleus in preoptic area
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area is much larger in males than females, homosexual men's sexually dimorphic nuclus looked like the female's
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hypothalamus very important to understand sex differences this is the brain region that talks to
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pituitary gland that causes release of hormone
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anterior pituitary regulates
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hormone secretion from the gonads
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nosuseptive or noxious stimulus
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info. leading to the likelyhood of experiencing pain and that's potentially damaging information (being burned)
-receptro proteins TrpV1 (changes in temp), even higher temp a delta fibers, hot right away- myelinated -TrpV2- high temp and captasin (chili pepers) chemical, slow signal - capsasin on c fibers- unmylinated -time delay with spicy -free nerve endings right at skin's surface sense heat |
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traveling of signal until pain is received
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nosuseption
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neurons in the hypothalamus that contain gonadotropin releasing hormone into pituitary gland
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which releases luteinizing hormone and follicle stimulating hormone
-testosterone released into blood from testes and goes back to negatively feedback at anterior pituitary gland and hypothalamus -high levels of testosterone act w/in brain and pituitary gland to negatively down regulate the production of GNRH, follicle stimulating hormone, lieutenzing hormone , and less testosterone is produced |
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some androgen receptors in the hippocampus, amygdala etc.
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not just in hypothalamus, androgens play roles in behaviors
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(regular touch) detecting things in the environment nerve ending is in periphery cell body that produces that nerve ending originates in the dorsal root ganglion (dorsal portion of spinal cord important for sensory, ventral portion important for motor output)
-axon derived from unipolar in dorsal root ganglion (c8) -multiple pathways at spinal cord detect at same level of thumb different sensations- touching and burning have two different cells that sense them and they run along the same spinal nerve tract |
1)sensory receptors send axons to the dorsal portion of the spinal cord
2)does not synapse goes straight up to the medulla where the first synapse occurs 3)at level of medulla it projects to thalamus by crossing over at the level of the medulla and up to the thalamus (right side of spinal cord projects to left side of thalamus and vice versa) |
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progestins
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hormones that help maintain pregnancy
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estrogen receptors play important roles in both sexes
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progesterone is more important for the birthing process allowing for egg implantation, reducing uterine contractions, allowing production of milk and lactation
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albert niemann
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purified cocaine from leaves
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amphetamines bind to
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monamine transporters, slows uptake of dopamine and increases dopamine release too, which makes it stronger than cocaine
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dorsal horn of the spinal cord important for
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sensory processing
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endorphin
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acts as mu and delta
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dynorphin
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acts as kappa receptors
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enkephalin
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bind mu and delta (endorphins)
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touch pathway
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decussation happening at medulla to thalamus
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testosterone does not affect mullerian system
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anti mullerian hormone regresses the mullerian system
-testosterone is converted to dihydrotestosterone and that further results in the development of male secondary sex characteristics -Dhy causes tissue around urethra to form prostrate gland, scrotum and penis |
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if androgens are absent
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prostrate fails to form and external skin grows into labia and clitoris
-if syr gene is present you will develop testes |
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antimullerian hormone causes mullerian ducts to not develop if no receptors to anct on
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hormone is invisible to system
-if you get rid of androgen receptors then system does not get masculinized further, but secondary sex characteristics are masculinized further |
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V1 is not very sensitive to just spots of light
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visual cortical cells require more specific environmental stimuli to be activated
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V1 sends axons to other cortical regions important for vision V2 V4 and inferior temporal region referred to as
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extrastriate areas
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ventral stream important for
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identifying objects
-includes occipitotemporal, inferior temporal frontal areas |
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dorsal stream
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important for locating an objecct
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in humans information about faces becomes more specific the more
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rostral the processing occurs
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anterior part of the dorsal stream merges with the motor cortex and includes neurons that have both
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visual and motor functions
-mirror neurons -these neurons are important for transforming visual info. into knowledge |
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neurons that control muscle contraction are
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located in ventral horn of the spinal cord
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within accumbens projects to
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gab-urgic neuron which also receives glutamate projections from prefrontal cortex hippocampus, amydala
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All MAOs are in
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Midbrain and hindbrain caudal regions of the brain
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V1 is not very sensitive to just spots of light
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visual cortical cells require more specific environmental stimuli to be activated
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V1 sends axons to other cortical regions important for vision V2 V4 and inferior temporal region referred to as
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extrastriate areas
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ventral stream important for
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identifying objects
-includes occipitotemporal, inferior temporal frontal areas |
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dorsal stream
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important for locating an objecct
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in humans information about faces becomes more specific the more
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rostral the processing occurs
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anterior part of the dorsal stream merges with the motor cortex and includes neurons that have both
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visual and motor functions
-mirror neurons -these neurons are important for transforming visual info. into knowledge |
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neurons that control muscle contraction are
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located in ventral horn of the spinal cord
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dopamine neurons are in
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midbrain in ventral tegmental area and substantia nigra
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within accumbens projects to
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gab-urgic neuron which also receives glutamate projections from prefrontal cortex hippocampus, amydala
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All MAOs are in
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Midbrain and hindbrain caudal regions of the brain
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second messengers
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amplify the effect of the ligand (aka the first messenger)
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compared to ionotropic signalling, metabotropic is
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slow and longer lasting
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glutamate containing neurons project to
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striatum
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glutamate synapse contain many proteins including multiple types of glutamate receptors, complex at synapse is called
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post synaptic density
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Glutamate
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an amino acid neurotransmitter, main excitatory neurotransmitter in the brain
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3 ionotropic glutamate receptors
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1) NMDA 2)AMPA 3)Kainate
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metabotropic glutamate receptors
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called mGluRs
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AMPA and Kainate glutamate receptors are
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ligand gated sodium or calcium channels (glutamate binds to receptors and allows the flow of ions in)
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NMDA glutamate receptors (complex) has 6 binding sites and glutamate is not the only ligand
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-both ligand gated and voltage gated channel (expelling Mg2+)
-glutamate binding ampa receptor opens allows the flow of sodium in this causes partial depolarization that pushes out magnesium, glutamate then binds NMDA receptor and allows NMDA receptor to open and this allows the flow of both sodium and calcium into the postsynaptic cell causing an even greater depolarization of the cell -glycine must also be bound for glutamate to open the channel |
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amine neurotransmitters
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acetylcholine, dopamine, serotonin
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each cone in the human retina has
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one of three classes of pigments
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color perception occurs in
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ganglion cells and brain (not at the photreceptor cells)
-cones don't detect color they are named for their relative wavelength peak |
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ganglion cells in each eye fire action potentials that travel through the
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optic nerve to the brain
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optic nerves cross the midline at the
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optic chiasm
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after the optic chiasm the axons are called
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are called
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gonadotropin releasing hormone of the hypothalamus projects and dumps into the bloodstream, then that hormone
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travels to anterior pituitary and release the tropic factor (lutenizing hormone and follicle releasing hormore) act at both the testies and ovaries
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most axons from the optic tract terminate on cells in the
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visual thalamus
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visual thalamus is called
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lateral geniculate nucleus
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testes are segregated into
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sperm producing cells and testosterone producing cells, releases from the testes and then goes back to negatively feedback both at the level of the anterior pituitary gland and the hypothalamus (regulate follicle stimulating hormone and luteinizing hormone and thus less testosterone will be produced)
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LGN neurons project to
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occipital cortex
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occipital cortex is called
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visual cortex, primary visual cortex, V1, also called striate cortex
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the projections from LGN to primary visual cortex are called
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optic radiations
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surrounding cortical regions are also critical for vision, these regions are called
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extrastriate cortex
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cells in visual cortex respond to more complicated stimuli
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ex: stimuli moving in certain directions
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(on center, off surround) bipolar and ganglion cells (in the retina) have concentric receptive fields with antagonistic center and surround
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light at center of the receptive field excites these cells (more action potentials)
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off center/ on surround
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light at center of receptive field inhibits these cells (fire less action potentials)
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cells in the LGN respond like cells in the retina
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can be activated by just spots of light
-6 layers -2 inner layers have relatively large cells -called magnocellular -4 outer layers relatively small cells -called parvocellular |
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input to magnocellular layers have relatively large receptive fields the input to these neurons is from many large ganglion cells in the retina called
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M cells
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magnocellular neurons do not show differential responses to different wavelengths of the electromagnetic spectrum
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are not involved in color discrimation
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input to parvocellular layers have relatively small receptive fields
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input comes from small ganglion cells in the retina (P-cells) that receive their inputs from individual cone cells (color vision)
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List all different types of breads/rolls/buns we stock on our line (17)
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challah bun, hot dog bun, sub rolls, p-rolls, o-rye, o-rolls, CW, Challah, BHW, BH, pecan raisin, sourdough, farm, rye, pump, ses sem, rustic
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10 slices are cut from which standard loafs of bread?
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rye, pump, ses sem, rustic
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8 slices are cut from which standard loaf of bread
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farm
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6 slices are cut from which standard loaf of bread
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sour dough
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how long do we double bake most of our bread
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20 mins
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