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25 Cards in this Set
- Front
- Back
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Greater risk at what period |
1st trimester |
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Effects can vary depending on gestational age at exposure. State them |
Awal 2 weeks all or none, spont abortion or nothing 2-8 weeks organogenesis affected so structural effects
>8 weeks growth affected and CNS dysf (limbs and organs already formed and no birth defect usually) |
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What abnormal effects?? |
Fetal loss FGR birth defect Impaired neurological function |
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What hypertensive drug can be teratogen |
ACE inhibitors Congenital malfor if 1st trimester and hypocalvaria Oligohydromnias if 2 or 3 trimester (dec fetal function of kidneys and even renal failure), can cause potters syndrome |
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Antiepileptic ?? |
Phenytoin, carbamezapine, valporate and phenobarbital (all first generat antiepileptics) Neural tube defect , cardiac defect , cleft palate and skeletal abnormalities (abnormal facial features and short fingers) |
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Ayya aktar antiepi byaamel neural tube defect and why w kif bhel l mawdu3 |
Valporic acid byaamel spina bifida Cz microsomal inducer so folic acid bytkasar bsr3a High dose supplementation of folic acid |
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Antibiotics ?? |
Aminoglycoside ototoxic Tetracyclin bone and teeth defect Fluroquinolone ciprofloxacin arthropathy (bone and cartilage) Sulfonamide displace bilirubin from albumin byaamele neonatal jaundic kernicetrus Chloramphenicol gray baby syndrome |
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What abx safe |
Penicillin cephalosporins erythromycin (hepatic injury to mom risk) |
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Shu keno yaato zamen for abortion |
Diethylstilbestrol (NSAISs) DES Hlaa laa laeno female reproductive effects on fetus (abnormal uterus development and infertility) |
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Shu keno yaato for morning sickness w le batalo |
Thalidoamide Batalo laeno phocomalia (limb defect) |
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Shu keno yaato for gastritis and ulcers |
Misoprostol Leads to abortion and malformations |
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Shu mafiye estaamel ekher trimester Tl3 awal trimester mafiye kmn |
NSAIDS cz premature closure of foramen ovale |
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Exposure to a drug causes same damage in all fetuses ??? |
No, genetic susceptibility btlaab dor |
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Fiye a3te Corticosteroids ? |
First trimester laa byaamel cleft palate Telet trimester baati for lung maturation Eza aande asthmatic mom and life and death lezem to consider ene a3ti |
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What radioactive isotope can be given in nuclear medicine imaging |
Technietium bynaata Iodine 131 la2 (can cross placenta and cause fetal thyroid and have long half life of 8 days ) |
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Shu aande folate antagonists |
Trimethoprim and methotraxate Byaamlo neural tube defect |
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Lithium?? |
Ebstein anomaly of heart (tricuspid low ) |
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Anticoagul?? |
Warfarin no cz Risk of cerebral hemorrhage And risk of bone and cartilage deformities in first trimester And opticc nerve atrophy |
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Shu baate anticoag in preg Shu fi risk?? |
Heparin or LMWH (no warfarin) - risk of osteoporosis |
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La weje shu mamnu3 estaamel |
Isotretinoin vit A Cranifacial anomalies Cardiac Thymic CNC Spont abortion in 20% Embryopathy in 20% |
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Shu fi shi ktir fi vit a |
Sawda |
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Alcohol ?? |
Facial abnormalities (soft philtrum, thin upper lip, small palpebral fissure, flat nasal bridgee) Most common preventable cause of ID (neurotoxic) DD SHort stature and weight b kel hayeto Microcephaly Impaired migration of neural and glial cells Heart defect (ASS VSD and tetralogy of falot) Hypotonia |
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Smokimggg ?? |
Aktar affects growth So risk of prematurity and FGR so inc risk of health problems awal ma ykhl2 Momkn risk of cerebral palsy and MR And later behavioral prnlms Inc SIDS and ADHD |
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How smoking affects |
VC vessels and CO impain o2 deivery |
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Cocaine amphetamine mdre shu |
Low birth weight Withdrawal symp Learning and behavioral disabilities Birth defect Kamn VC |
