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61 Cards in this Set

  • Front
  • Back
amitriptyine
elavil
nortriptyline
pamelor
imipramine
tofranil
desipramine
norpramin
clomipramine
anafranil
TCA MOA
NE and 5HT reuptake inhibitor
TCA side effects
cardiovascular
anticholinergics
sedation
weight gain
sexual dysfunction
Olanzapine
zyprexa
sedation
weight gain
orthostatic hypotension
anticholinergics
risperidone
risperdal
prolactin elevation
orthostatis
sexual dysfunction
quetiapine
seroquel
sedation
hypotension
HA
weight gain
lenticular formation
ziprasidone
geoden
mild sedation
minimal weight gain
QTc prolongation
Clozapine
Clozaril
Agranulocytosis
seizures
sedation
hypotension
salivation
weight gain
aripiprazole
abilify
anxiety
HA
nausea
constipation
phenelzine
nardil
tranylcypromine
parnate
MOA MAOI
irreversible inhibition of MAO A and MAO B to raise 5HT DA NE
MAOI side effects
hypotension
dizziness
weight gain
insomnia
cardiac effects
constipation
sexual disfunction
Tyramine- absolute contraindications
aged cheese
aged meats
tap beer
sauerkraut
soy sauce
banana peel
marmite
tyramine- moderate contraindications
red/white wine
canned or bottled beer
drug interactions of tyramine
merperidine- agitation, seizure, coma
SSRI, TCA, stimulants, levodopa- hypertensive crisis
selegiline
emsam
MAO A and dose-dependent MAO B. food contstrictions start at 9 mg
citalopram
celexa
only 5HT inhibitor
escitalopram
lexapro
s-entatiomer of citalopram
fluoxetine
prozac, sarafem
long t1/2
active metabolite
2D6, 3A4, 2C inhibition
fluvoxamine
luvox
1A2, 3A4, 2C inhibitor
paroxetine
paxil
anticholinergic
short t1/2
2D6 inhibition
sertraline
zoloft
active metabolite
SSRI side effects
nausea
diarrhea
sedation
insomnia
anxiety
HA
sexual side effects
night mares
night sweats
serotonin syndrome
venlafaxine
-effexor
-SNRI (NE >150 mg)
-active metabolite
-N/D
-HA
-hypertension
-sexual dysfunction
-nervousness
-insomnia
-XR reduces SE
duloxetine
-cymbalta
-5HT, NE reuptake inhibitor
-metabolized by 2d6, 1A2
-Nausea
-insomnia
-headache
-sexual dysfunction
Bupropion
-wellbutrin
-NDRI
-contraindications: sz, bulemia, zyban
-GI upset
-restlessness
-insomnia
-sz
-HA
-NO SEXUAL SE
nefazodone
-serzone
-SRI (S2 antagonist, NE at higher dose)
-3A4 inhibitor
-only generic due to liver failure
-dry mouth
-nausea
-dizziness
-constipation
-sedation
-liver failure
-NO SEXUAL SIDE EFFECTS
Mirtazapine
-remeron
-alpha 2, 5HT3, 2A, 2C antagonist
-increases NE and 5HT
-weight gain
-sedation
-dry mouth
-constipation
-NO SEXUAL SIDE EFFECTS
Trazodone
-heterocyclic antidepressant
-increases 5HT
-H1 blocker
-used for insomnia
SJW
-hypericum
-SSRI
-COC interaction
Lithium- MOA, what for
-classic mania
-effects anion exchanged and sodium transport
-normalizes transmission of 5HT, HE, DA
Lithium- pk
-t1/2 =24 hours
-renal!
-effects in 5-10 days
Lithium levels
-manic: 0.9-1.4
-maintenace: 0.45-0.6
-blood levels every week until stable
Lithium- monitor
-na
-ecg
-bun, Scr
-thyroid
-preg
-wbc
-urinalysis/ kidney function
lithium- short term side effects
-GI upset
-tremor
-poly liquids
-fatigue
lithium- chronic side effects
-tremor
-poly liquids
-wbc
-acne
-weight gain
-hypothyroid
lithium- teratogenicity
cardiovascular congenital effects
Lithium toxicity
-mild-severe (1.5-2.5)
-hold dose and care for them
lithium- advantages
-control mania without drugged effect
-normalize mood
-prophalactic
-relapses are shorter and less severe
-blood monitoring gives accurate titration
-low cost
lithium- disadvantages
-narrow window
-patient compliance for watching for toxiticy
-lag period before TM works
-prophylatic effect is 6 mo to a year
-expense of blood draws
-makes rapid cyclers worse
VPA (BP)
-rapid cyclers and mixed episode
-3-5 days
-enhance GABA activity by effecting Na channels
-hepatic metabolism (glucuronidation, oxidation)
-50-120 mcg/ml
-cbc
-lft
-GI distress
-sedation
-weight gain
-alopecia
-thrombocytopenia
-inc. LFT
-pancreatitis
-hepatotoxicity
carbamazapine (BP)
-rapid cyclers and mixed episode
-inhibits transmission at Na channel
-hepatic 3A4 metabolism
-1-2 weeks for effect
-8-12 mg/l
-get level 12 hr post 5 day dose
-cbc
-electrolytes
-LFTS
-sedation
-ataxia
-nausea
-rash
-hyponatremia
-aplastic anemia
-thrombocytopenia
lamotrigine (BP)
-BPII
-delay time of occurence of mood episodes
-inhibits VG Na channels
-titrate to avoid rash
-interacts with VPA, CBZ
Anticonvulsants (BP)
topiramate
oxcarbamazine
gabapentin
tiagabine
atypical antipsychotics (BP)
-all work
-dose high
-refractory-this and AED
carbamazapine
-tegretol
-partial, tonic-clonic
-metabolized by 3A4
-autoinduction
-CNS SE
-SIADH
-leukopenia
-aplastic anemia
-hepatitis
-rash
-4-12 mg/ml
-induces cyp, udp
phenytion
-dilantin
-partial, tonic-clonic
-excessive binding
-2c9, 2C19 metabolized
-CNS SE
-rash
-gingical hyperplasia
-hirstriusm, coarse facial features
-osteoporosis
-cyp, ugd inducer
-interactions with antacids and enteral feedings
-10-20 mg/ml (1-2 unbound)
VPA
-depakote
-all seizures
-saturable binding
-glucuronidation, minor cyp
-CNS SE
-platelet effects
-parkinsonism
-hepatotoxicity
-pancreatitis
-weight gain
-menstrual cycle abnormalities
-50-100 mg/ml
-inhibits cyp and ugd
-can be induced
pb
-partial, tonic-clonic
-20% renal, 50% cyp
-long t1/2
-sedation, decreased cog function
-megaloblastic anemia
-osteomalacia
-rash
-excites kids
-induces cyp, ugt
-15-20 mg/ml
gabapentin
-neurontin
-partial
-saturable binding
-renal
-no interaction
-weight gain
-CNS
-edema
pregabalin
-lyrica
-renal
-no interactions
-weight gain
-euphoria
-cns
lamotrigine
-lamictal
-all seizures
-gluc, t1/2-24, 15, 60
-no induction, inhibition
-not as much CNS
-ha
-insomnia
-rash- go slow!
-4-20 mg/ml
topirimate
-topamax
-all seizures
-low binding
-renal
-inhibits 2C9, induces 3A4
-CNS
-kidney stones
-weight loss
zonisamide
-zonegran
-partial, absence, myoclonic
-63 hours
-no induction or inhibition
-3A4
-CNS
-kidney stones
-rash
-Scr
-sulfa allergy
levetiracetum
-keppra
-partial, absence, myoclonic
-unbound
-renal, non-cyp
-no interactions
-10-50 mg/ml
-sedation
-behavior
-weight neutral
oxcarbamazine
-trileptal
-partial
-no autoinduction
-inhibit 2C19
-induce 3A4, UGT
-CNS SE
-abdominal pain
-tremor
-hyponatremia