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17 Cards in this Set

  • Front
  • Back
Steps TCA
6 steps in cycle + preceding PDH
Net Energy 1 cycle TCA
15 ATP
4 NADH * (3ATP)
1FADH2 * (2ATP)
1 GTP * (1ATP)
1st step after PDH
citrate synthetase
Citrate synthetase
releases CoASH
spontaneously initiates the cycle
No E produced
Allosteric inhibitor Succinyl-CoA (4th int)
2nd step TCA
isocitrate dehyrdogenase
Isocitrate dehydrogenase
redox rxn
+1 NADH (3 ATP)
releases CO2
3rd step TCA
a-Ketoglutarate dehydrogenase
a-Ketoglutarate dehydrogenase
release CO2
+1 NADH
Allosteric inhibitor Succinyl-CoA (4th int) , GTP, NADH
Substrates in REDOX
NAD+ is the oxidant
4 step in TCA
Succinyl CoA synthetase
Succinyl CoA synthetase
+1 GTP
Confusing Name
5th step in TCA
succinate dehydrongenase
succinate dehydrongenase
+1 FADH2
ONly TCA enzyme attached to inner membrane (closer to the ox phos
6th step TCA
Malate dehydrongenase
Malate dehydrongenase
Produces NADH
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C - citrate
I - isocitrate
K - a-ketoglutarate
S - succinyl CoA
S - succinate
F - fumarate (Not Enzyme)
M - malate
O - oxaloacetate (Not Enzyme)
TCA steps Regulated
Steps 1,2,3
All by allosteric inihbitor