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20 Cards in this Set
- Front
- Back
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where are the enzymes of the TCA located?
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mitochondrial matrix
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pneumonic for TCA intermediates?
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old chinese and indian kings sell sugar for money-oxaloacetate, citrate, aconitate, isocitrate, alpha ketoglutarate, succinyl CoA, succinate, fumarate, malate
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what is the committed step of the TCA?
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citrate synthase
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what inhibits citrate synthase?
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ATP, NADH, citrate and succinyl CoA
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what enzyme complex is nearly identical to the PDH complex?
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alpha ketoglutarate complex
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what produces the first CO2?
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isocitrate dehydrogenase
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what produces the second NADH?
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alpha ketoglutarate
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difference between PDH complex and alpha KG?
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not regulated by phosphorylation
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what are the four dehydrogenases?
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isocitrate, alpha KG, succinate and malate
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what enzyme of the TCA is also part of the ETC?
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succinate dehydrogenase
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what inhibits succinate dehydrogenase?
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malate
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which step has a positive delta G?
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malate DH
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genetics of PDH?
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x-linked dominant
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how does arsenic poisoning work?
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affects enzymes using lipoic acid-PDH, alpha KG DH and alphaketoacid DH
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what is in the urine of a person with fumarase deficiency?
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succinate, alpha KG, citrate and malate
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cause of fumarase deficiency?
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glutamate at residue 319 replaced by glutamine
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which intermediates can be used in gluconeogenesis?
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malate and oxaloacetate
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which intermediates can be used in aa synthesis
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alpha KG, oxaloacetate
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what reaction turns pyruvate into oxaloacetate?
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pyruvate carboxylase
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amino acids can replenish which intermediates?
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fumarate, pyruvate and alpha KG through glutamate
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