Tb,hiv,

Front 1

what is BCG? (Bacillus of Calmette and Guerin)?

Back 1

Vaccine against TB

Front 2

List 5 TB drugs (RIP-ES)

RIP -> hepatoxicity
ES: renal toxicity

Back 2

R: Rifampin
I: isoniazid
P: Pyrazinamide
E: Ethambutol
S: Streptomycin

Front 3

INH
S/SX of hepatoxicity
(flu-like symptoms)

Back 3

fatigue, weakness, n/v and dark urine, yellow eyes

Front 4

INH
To prevent peripheral neuropathy

Back 4

Vitamin B6 (pyridoxine) 50 mg PO QD

Front 5

Toxicity of streptomycin

1.
2.

Back 5

1. Nephrotoxicity
2. otoxicity

Front 6

What is Rifamate?

Back 6

INH + rifampin (cap) BID

Front 7

What is Rifater?

Back 7

INH + rifampin + pyrazinamide QD, always on empty stomach

Front 8

TB tx for HIV + pt

1. 1st 8 weeks
2. the following 16 weeks

Back 8

1. INH, rifampin, pyrazinamide and ethambutol for the 1st 8 weeks

2. INH and Rifabutin for 16 weeks

Front 9

Etravirine (Intelence)

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 9

C. NNRTIs

Front 10

Nevirapine (NVP)
which class?

A. Protease inhibitors (PIs)
B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)
C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 10

C. NNRTIs

Front 11

Efavirenz (EFV)
which class?

A. Protease inhibitors (PIs)
B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)
C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 11

c. NNRTIs

Front 12

Abacavir (ABC) Ziagen

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 12

B. NRTIs

Front 13

Didanosine (ddI) Videx

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 13

B. NRTIs

Front 14

Lamivudine (3TC) Epivir

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 14

b.NRTIs

Front 15

Stavudine (d4T) Zerit

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 15

b. NRTIs

Front 16

Zidovudine (AZT) (Retrovir)

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 16

b. NRTIs

Front 17

Emtricitabine (FTC) Emtriva

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 17

b. NRTIs

Front 18

Amprenavir (APV) (Agenerase)

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 18

a. PI

Front 19

Indinavir (IDV)

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 19

A. PI

Front 20

Nelfinavir (NPV) Viracept

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 20

A. PI

Front 21

Ritonavir (RTV) NOrvir

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 21

A. PI

Front 22

Saquinavir (SQV)

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 22

A. PI

Front 23

Fosamprenavir (EPV) (Lexiva)

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 23

A. PI

Front 24

Atazanavir (ATZ) (Reyataz)

which class?

A. Protease inhibitors (PIs)

B. Nucleoside Reverse Transcriptase inhibitors (NRTIs)

C.Non-nucleoside reverse Transcriptase inhibitors (NNRTIs)

Back 24

A. PI

Front 25

PI (Protease inhibitors) Class effects

Back 25

1. GI intolerance
2. Hyperlipidemia
3. Hyperglycemia
4. Increased wt gain
5. Lipodystrophy
6. 3A4 inhibitors

Front 26

Indinavir (IDV) Crixivan

Back 26

1. on empty stomach, kidney stones (drink plenty of water)

2. Very sensitive to mositure; must store with desiccant in container. Without desiccant capsule are good for 3 days

Front 27

Kaletra (Lopinavir + Ritonavir)

** ritonavir increase lopnavir concentration by 100 folds)

Back 27

PO --> not in the fridge

oral solution --> in the fridge (42% ETOH)

Front 28

Ritonavir (RTV) NOrvir

Always take with food

Capsules: fridge or not fridge

Solution: fridge or not fridge

Back 28

cap: fridge

solution: not fridge

AE: paresthesias

Front 29

Invirase (Saquinavir) SQV

hard gel

tablet

Back 29

hard gel: 200 mg

tab: 500 mg (store at room temperature)

Front 30

BBW of Aptivus (TPV) Tiprinavir?

Back 30

Intracranil hemorrhage

Front 31

If patient has high lipid prolife, which PI (protease inhibitor) will be a good choice?

Back 31

Atazanavir (ATZ) Reyataz

Front 32

pt counseling on

didanosine (ddi) (Videx, Videx EC)

Back 32

1. On empty stomach
2. Sx of neuropathy
3. risk of pancreatitis
3. retinal pigmentation

Front 33

Lamivudine (3TC) (Epivir)

Also for??

Back 33

Hep B

100 mg QD x 1 year

Front 34

3 ds-->

1. Pancreatitis
2. Peripheral neuropathy

Back 34

d look like P

ddi: didanosine
ddc: zalcitabine
d4t: Stavudine

Front 35

Side effects of zidovudine (AZT, ZDV) (Retrovir)

1.

2.

Back 35

1. myelosuppression
a. anemia
b. neutropenia

2. Purple toenails

Front 36

What are class effects of NRTIs?

Back 36

1. Lactic acidosis

2. HA

Front 37

Which one, the only one, NRTI requires an empty stomach?

At least 1 hour before or 2 hours after a meal

Back 37

ddi (didanosine, Videx, Videx EC)

Front 38

Abacavir (ABC) Ziagen

Back 38

hypersensitivity

Front 39

ddi (didanosin) (Videx, videx EC)

Back 39

on empty stomach,

eye exam (q6m)

Front 40

Lamivudine (3TC)

Back 40

also for Hep B

Front 41

Stavudine (d4t) (Zerit)

Back 41

1. Lipodystrophy
2. Do not take with anacids

Front 42

zalcitabine (ddc)

Back 42

mouth ulcers (triamcinolone dental paste)

Front 43

what is the unusual effect about
Emtricitabine (FTC) Emtriva?

Back 43

a darkening of the palms and soles can occur after 3 months of use

Front 44

What are major AE of

Efavirenz (EFV) (Sustiva) NNRTI?

Back 44

1. CNS symptoms (vivid dreams, halluncinations, dizziness, confusion)

2. False cannabinoid test

Front 45

What are the class effects of NNRTIs?

Back 45

1. Hepatotoxicity

2. Rash (Steven Johnson's) 3A4 inducer

Front 46

What is Atripla?

(Truvada + Sustiva)

Back 46

The first once-daily, SINGLE tablet HIV regimen

Truvada (tenofovir NNRTI + emtricitabine NRTI)

Sustiva (efavirenz) NNRTI

Front 47

What is

Enfuvirtide (Fuzeon)
Selzentry (maravircor)?

Back 47

entry inhibitors

Front 48

Fuzeon

IV or PO?

Back 48

90 mg SC BID

Front 49

Selzentry (maraviroc)

IV or PO?

Back 49

150 mg BID with other 3A4 inhibitors
or

300 mg BID with all NRTIs

or 600 mg BID with 3A4 inducers

Front 50

What are 3A4 inducers?

Back 50

efavirenz
rifampin
carbazepine, phenobarbital and phenytoin

Front 51

Why are there PO, IV and solution forms of zidovudine?

Back 51

For HIV infection in pregnancy
PO: during pregnancy
IV: during labor
solution: for baby (from 6 hours to 6 weeks treatment)

Front 52

List 4 HIV drugs should take on empty stomach.

Back 52

1. didanosine (Videx EC, ddi) 30 mins before and 2 hours after

2. Indinavir (Crixvan) IDV, with plenty of water

3. Fosamrenavir (Lexiva) oral suspension in adults

** suspension in children can take with foods***

4. Efavirenz (Sustiva) (EFV)

Front 53

HIV med storage

Aptivus (tipranavir)

"capsule"

Back 53

Before opened the bottle, caps should be refridged. Once open, room tem for 60 days

Front 54

HIV Med storage

crixivan
"capsule"

Back 54

room temperature, originial containers

Front 55

HIV Med storage

Most HIV oral solutions can be fridged. One exception is...

Back 55

Norvir (ritonavir)

dispense in original container @room temperature; DO NOR FRidge

Front 56

What are the vaccines recommened in HIV population (NOT AIDS)?

MMR should not be administered to pt with severely symptomatic HIV /AIDS;

Back 56

1. Hep A
2. Hep B
3. Influenza
4. Pneumococcus
5. MMR
6. DPT

HIV (no symptoms) with CD4 count >200

Front 57

what are DOCs for PCP in HIV patients?

Back 57

Bactrim + Prednision for 21 days

Front 58

What are the DOCs for MAC in HIV patients?

Back 58

MAC for MACrolides

1. CLarithromycin (Bixain)
2. azithromycin (Zithromax)

Front 59

CMV infection in HIV patients

1. Foscarnet IV line

2. Ganciclovir (Cytovene)

3. Cidofovir (Vistide)

Back 59

1. IV line

2. Cytovene IV line first and then PO
(watch for seizure)

3. IV line, must take with Probenecid (to prevent kidneys damage)

Front 60

What is Vitrasert?

Back 60

Ganciclovir implants
--> a surgically implanted directly into the eye

--> Must change every 6 months

--> for the Tx of CMV retinitis

Front 61

What is Vitravene?

Back 61

Fomivirsen (for CMV)
A shot directly into the eye

Front 62

What is DOC for Hep C in HIV patients?

Back 62

1. Interferon
2. Pegasys, PEG-Intro
3. Ribavirin (Rebetol; Copegus)